Graphical abstract. Credit: Cell Reports (2026). DOI: 10.1016/j.celrep.2026.117414 Michigan State University researchers have identified how ovarian cancer cells become resistant to chemotherapy and discovered a protein that, when blocked, can restore the drug's effectiveness. The findings, published in Cell Reports, center on cisplatin, a widely used chemotherapy drug first discovered at MSU in 1965 and still considered among the gold standards for treating ovarian and other cancers.