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Sarkaria Jann

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Articles

Uncovering the signaling networks of disseminated glioblastoma cells in vivo with INSIGHT

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By Ryuhjin Ahn, Alicia D’Souza, Lawrence Long, Yufei Cui, Jennifer Gantchev, Gerard Baquer, Danielle M. Burgenske, Katrina K. Bakken, Lauren Ott, Brett Carlson, Grace Zhou, Ishwar N. Kohale, Charles A. Whittaker, Tomer M. Yaron-Barir, Jeffrey Wyckoff, Terry Burns, Rachael A. Vaubel, Cameron T. Flower, Wei Huang, Jared Johnson, Nathalie Y. R. Agar, Forest M. White, Heidi Temple, Ann Tuma, Josie Ursini-Siegel, Sarkaria Jann
| Nature Verified
Abstract Dysregulation of intracellular signaling networks underpins cancer. Yet, resolving signaling networks within distinct or rare cell types in cancer in vivo has been unattainable. Here we develop INSIGHT by integrating cell sorting with mass spectrometry to enable quantitative phosphoproteomics and proteomics of discrete cell types from fixed tissues. Using INSIGHT, we map the signaling network within disseminating glioblastoma cells from patient-derived xenografts implanted in mice.
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