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Sarugan Sathianathan

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Articles

Embryonic dopaminergic neuron activity sustains lifelong locomotion in Drosophila

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By Aishwarya Padmanabhan, Daniel Monteiro Rahman, Cheng Huang, Nikolaos Konstantinides, Abdul Issa, Ruibao Zhu, Salah Khorbtli, Sarugan Sathianathan, Bastien Le Flohic, Lauren Assanga Bisse, Bertrand Mollereau
| Cell Reports Verified
Results Movement is present at all stages of Drosophila development, including peristaltic waves (hereinafter referred to as twitching) at the embryonic stage,2,29 crawling in larvae,14,30 and walking in adults.5,31 DANs and their receptors are present early during development, at the embryonic stage (Figure 1A), allowing us to test whether early DAN activity is essential for locomotor function development and, if so, to determine the consequences of chronic DAN inactivation during early...
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