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Articles

The MYB-related transcription factor MYPOP acts as a selective regulator of cancer cell growth

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By Johannes Strunk, Sascha Wagner, Kirsten Freitag, Tatjana Döring, Tobias Bopp, Matthias Klein, Krishnaraj Rajalingam, Gregory Harms, Federico Marini, Carina Osterhof, Marc Schneider, Alina Henrich, Martin Suchan, Barbara Schrörs, Mustafa Diken, Alena Hüppner, Mahwish Sial, Matthias Plath, Mika B. Sheriff, Annekathrin S. Nedwed, Thomas Hankeln, Andrea Nubbemeyer, Mario Perkovic, Sebastian Kreiter, Anne Kölsch, Luise Florin
| Nature Verified
Abstract The MYB-related transcription factor and partner of profilin (MYPOP or p42POP) is a ubiquitously expressed yet understudied protein recently identified as a restriction factor of oncogenic human papillomaviruses (HPV) and proposed tumor suppressor. Here we show that in HPV-transformed cervical cancer cells, MYPOP induces alterations in cell morphology, silences viral and cellular oncogenes including E6 and MYC, and stimulates the release of the cancer-killing cytokine interleukin-24.
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