Sauyeun Shin

Keywords bone marrow adipocytes anucleate adipocytes metabolism adipokines hematopoiesis Research topic(s) CP: metabolism Introduction Bone marrow adipose tissue (BMAT), made up of bone marrow adipocytes (BMAds), is a major yet still incompletely characterized component of the bone marrow (BM).1,2 In both humans and rodents, BMAT displays structural and metabolic features that distinguish it from classical adipose tissues (ATs) such as subcutaneous (SCAT) and visceral AT.1,2 BMAT is unusual...

1 Introduction Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related death in industrialized countries, with a 5-year survival rate below 10% [1]. This poor prognosis is largely due to late diagnosis, often at metastatic stages, and the limited response of patients to first-line chemotherapies, Gemcitabine/Abraxane and FOLFIRINOX (35% and 32% response rates, respectively) [2].

Abstract Cancer cells rely on mitochondria for their bioenergetic supply and macromolecule synthesis. Central to mitochondrial function is the regulation of mitochondrial protein synthesis, which primarily depends on the cytoplasmic translation of nuclear-encoded mitochondrial mRNAs whose protein products are imported into mitochondria.