Scarlett J. Barker

Editor’s summary Despite its seriousness, anorexia nervosa has limited treatment options. Chen et al. report that acyl CoA binding protein (ACBP), a conserved peptide known to induce hunger, is particularly low in hospitalized anorexic patients with poor prognosis.

Editor’s summary Vision loss in the late stages of neovascular age-related macular degeneration (nvAMD) is mainly caused by the formation of new blood vessels in the choroid layer of the eye. Current therapeutic strategies to inhibit choroidal neovascularization (CNV) are only partially effective. Dong et al. used a CNV mouse model and tissue samples from patients with nvAMD to show that natural killer cells accumulated in the choroid layer of the diseased eye.

Abstract Omic analysis of clinical specimens undergoing histological transformation defines targetable drivers to prevent plasticity and treatment resistance. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily INTRODUCTION Cancer cell plasticity may be defined as the ability of a cell to reprogram and transdifferentiate into an alternative phenotype resembling a distinct developmental lineage.