Stephanie DeMarco on Muck Rack

Stephanie DeMarco

Verified
United States
As seen in: The Scientist, MSN Canada, Nature, Los Angeles Times, Los Angeles Times en Espanol, The Toronto Star, Phys.org, The Minnesota Star Tribune, The Seattle Times, The San Diego Union-Tribune, Discover Magazine and
sci-steph.bsky.social Managing Editor @DrugDiscovNews | @AAASMassMedia ‘19 at @latimes | PhD in Mol Bio @UCLA | theater nerd | travel adventurer | she/her
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Articles

Vitamin D-Like Drug Plus Chemotherapy Proves Safe in Pancreatic Cancer Trial

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By Stephanie DeMarco Verified
| The Scientist Verified
One of the reasons pancreatic cancer is so difficult to treat doesn’t have to do with the tumor cells themselves but with the dense mesh of extracellular matrix surrounding them. In pancreatic cancer, fibroblasts become activated, leading to the production of this physical barrier that is thought to reduce the effectiveness of chemotherapy. This matrix also promotes an immunosuppressive environment around the tumors, preventing immune cells from attacking the cancer, allowing it to flourish.
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Engineered Enzymes Streamline Synthesis of an Oral Cholesterol Drug

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By Stephanie DeMarco Verified
| The Scientist Verified
Often described as “Goldilocks drugs,” macrocyclic peptides are smaller than biologics like antibodies but larger than small molecules. With their just-right size, macrocyclic peptides can travel into spaces too small for biologics to reach and, thanks to their structural rings of amino acids, can target protein-protein interactions that evade small molecules.
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Multiomics Reveals How Macrophages Contribute to Liver Disease

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By Stephanie DeMarco Verified
| The Scientist Verified
Using spatial multi-omics, researchers identified shifting macrophage populations in MASLD progression, identifying markers to aid patient stratification in clinical trials. Written byStephanie DeMarco, PhD Distinct populations of liver macrophages contribute to the progression of metabolic dysfunction-associated steatotic liver disease.
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