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Articles by Scott EE
CYP3A4 and CYP3A5: the crucial roles in clinical drug metabolism and the significant implications of genetic polymorphisms
Cytochrome P450 (CYP450) is the most significant phase I drug metabolizing enzyme in the human body, and approximately 75–90% of commonly utilized clinical drugs are metabolized by CYP450 (Lee et al., 2024; Zhou, Liu & Chowbay, 2009). Currently, 57 CYP-encoding genes and 58 pseudogenes are known to exist on human chromosomes, which can be further divided into 18 families and 43 subfamilies based on amino acid sequence similarity (Zhao et al., 2021b).
Transcriptome analysis during 4-vinylcyclohexene diepoxide exposure-induced premature ovarian insufficiency in mice
Transcriptome analysis during 4-vinylcyclohexene diepoxide exposure-induced premature ovarian insufficiency in mice 1The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China 2Gansu Provincial Clinical Research Center for Gynecological Oncology, the First Hospital of Lanzhou University, Lanzhou, Gansu, China DOI 10.7717/peerj.17251 Academic Editor Vladimir Uversky Subject Areas Biochemistry, Bioinformatics, Genetics, Molecular Biology, Toxicology Keywords Premature ovarian...
Geology and taphonomy of a unique tyrannosaurid bonebed from the upper Campanian Kaiparowits Formation of southern Utah: implications for tyrannosaurid gregariousness
Introduction Monodominant large theropod dinosaur bonebeds are rare in the geologic record.
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