Sean Brady on Muck Rack

Sean Brady

Kamloops
As seen in: Nature, Wiley Online Library, PLOS, American Chemical Society, Analytical Chemistry, Digital Spy, Cell Press, The World Bank Research Observer, The Province, Ultiworld and
Reporter @KamThisWeek, photos sometimes
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Sean

Contact Sean, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Mode of action guided metagenomic natural product discovery reveals convergent evolution of a ClpP-targeting motif

|
By Jingbo Kan, Adrian Morales-Amador, Yozen Hernandez, Jan Burian, Cecilia Panfil, Melinda A. Ternei, Robert E. Boer, Abir Bhattacharjee, Sean Brady, Seán Brady, Kaylyn Spotton
| Nature Verified
Abstract The discovery of natural products with specific modes of action from metagenomes remains challenging. Here, we present resistance-CONKAT-seq, a pipeline that links biosynthetic gene clusters (BGCs) to self-resistance genes, enabling identification of metabolites with desired molecular targets. Using clpP-directed resistance-CONKAT-seq, we identify the calprotamides, which activate native ClpP and enhance its activity.
Open in Who Shared Issue with article?

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma - Nature

|
By Swathi V. Iyer, David Hsieh Verified, Xuanhua P. Xie, Sean Brady, Seán Brady
| Nature Verified
Abstract Glioblastoma is incurable and in urgent need of improved therapeutics1. Here we identify a small compound, gliocidin, that kills glioblastoma cells while sparing non-tumour replicative cells. Gliocidin activity targets a de novo purine synthesis vulnerability in glioblastoma through indirect inhibition of inosine monophosphate dehydrogenase 2 (IMPDH2). IMPDH2 blockade reduces intracellular guanine nucleotide levels, causing nucleotide imbalance, replication stress and tumour cell death2.
Open in Who Shared Issue with article?

DNA glycosylases provide antiviral defence in prokaryotes - Nature

|
By Amer A. Hossain, Christian F. Baca, Søren Heissel, Sean Brady, Seán Brady, Phoebe Rice
| Nature Verified
Abstract Bacteria have adapted to phage predation by evolving a vast assortment of defence systems1. Although anti-phage immunity genes can be identified using bioinformatic tools, the discovery of novel systems is restricted to the available prokaryotic sequence data2. Here, to overcome this limitation, we infected Escherichia coli carrying a soil metagenomic DNA library3 with the lytic coliphage T4 to isolate clones carrying protective genes.
Open in Who Shared Issue with article?
See all 570 articles
 •  Privacy  •  Terms  •  Security and Legal  •   •   •   • 

© 2026 Muck Rack

SOC 2® Certified