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Articles by Sen Chen
Mechanism and experimental validation of a network pharmacology-based approach of Huoluo Yinao formula in treating chronic cerebral hypoperfusion
Chronic cerebral hypoperfusion (CCH) is a cerebral dysfunction caused by insufficient cerebral perfusion, and Huoluo Yinao (HLYN) formula is a traditional Chinese medicinal formula used for CCH treatment. We investigated the specific mechanism of HLYN formula on CCH through network pharmaco-logical analysis and in vivo experiments.
JMJD3-mediated HADH demethylation orchestrates hepatocyte maturation through fatty acid β-oxidation-dependent histone acetylation
Abstract Functionally mature hepatocyte generation requires coordinated genetic, metabolic, and epigenetic regulation. Although transcriptional regulation governing hepatocyte differentiation has been extensively studied, how metabolic remodeling interacts with epigenetic regulation during hepatocyte maturation remains poorly understood.
Moderate-temperature DNA cleavage activity of TtAgo activated by dCTP/TthSSB for one-step isothermal microRNAs detection
Abstract Thermus thermophilus Argonaute (TtAgo) is a DNA-guided endonuclease promising for gene editing and molecular diagnostics. However, its high-temperature dependence (65–85 °C) restricts its utility in moderate-temperature scenarios. Here we show that combining deoxycytidine triphosphate (dCTP) with the single-stranded DNA-binding protein from T. thermophilus (TthSSB) enables robust TtAgo activity within 37–60 °C.
Generation of proliferative hESC-derived grape-clustered hepatocyte organoids with multipolar architecture as regenerative counterpart via synergy of YAP and IGF2 pathways
Abstract Primary human hepatocyte (PHH)-derived organoids form grape-like clusters with proliferative capacity, hepatocyte functionality, and multipolar polarity, serving as valuable models for liver biology and therapeutics. However, deriving comparable organoids from human embryonic stem cells (hESCs) remains difficult.
Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development
1 Introduction Congenital hearing loss, the most prevalent sensory disorder worldwide [1], arises from genetic mutations in over 50% of cases [2]. Mutations in the Gap junction protein beta 2(GJB2) gene are the most common genetic cause of non-syndromic hereditary deafness [3], accounting for more than 25%–50% of all cases of hereditary hearing loss [4, 5].
Anisotropic 3D‐Printed Carbon Fiber‐Reinforced Liquid Metal Elastomer for Synergistic Enhancement of Electrical Conductivity, Thermal Performance, and Leakage Resistance
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma71012-sup-0001-SuppMat.docx5.2 MB Supporting Information References 1, , , , Adv. Mater. 2022, 34, 2106787. 2, , , , , , , , , , , , , , , , , , , Nat. Electron. 2024, 7, 51. 3, , , , , , , , , , , Nat. Mater. 2021, 20, 859. 4, , , , , Appl. Phys. Rev. 2023, 10, 021308. 5, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , et al., Science 2022, 375, 1411. 6, , , , Nat. Nanotechnol.
Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion
ResearchCell biologyOncology Open Access | 10.1172/JCI192368 J Clin Invest. https://doi.org/10.1172/JCI192368. Copyright © 2025, Ma et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract TMPRSS2:ERG gene fusion (T:E fusion) in prostate adenocarcinoma (PCa) puts ERG under androgen receptor (AR) regulated TMPRSS2 expression.
Research on the relationship and prediction model between nighttime lighting data, pm2.5 data, and urban GDP
With the development of electricity, artificial lighting has rapidly evolved, altering the traditional lifestyle of working with the sun and resting with the moon. It has met the needs of human nighttime activities. Industrial and domestic electricity usage has greatly improved living conditions, and the application of lighting electronic technology in daily life has profoundly changed and influenced people’s modes of production (Liu, 2023).
RsWRKY49 promotes cold tolerance via activating the expression of RsCBF2 and RsNR2 in radish (Raphanus sativus L.)
Conflict of Interest The authors declare that they have no competing interests. Supporting Information Filename Description tpj70256-sup-0001-FigureS1.tifTIFF image, 445.4 KB Figure S1. RsWRKY49 is induced by low temperature. (A, B) RsWRKY49 is a cold-inducible gene as indicated by RNA-seq (A) and RT-qPCR (B) under cold treatment in radish (‘NAU-YH’). (C) The expression profile of RsWRKY49 in the different tissues of radish (‘NAU-LB’). tpj70256-sup-0002-FigureS2.tifTIFF image, 1 MB Figure S2.
Divergent Synthesis of Polysubstituted 1,2-Dihydropyridines and Pyridines through Manganese-Mediated Radical Cascade Cyclization of Tertiary Enamides
The Journal of Organic Chemistry Cite this: J. Org. Chem. 2025, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
Visible Light‐Promoted Cascade Sulfonylation‐Cyclization‐Aromatization of Tertiary Enamides to Access Multi‐substituted Pyridines and 1,2‐Dihydropyridines
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description adsc202401516-s1-SI_1.docx797.1 KB Supplementary adsc202401516-s2-SI_2.pdf9.5 MB Supplementary
Manganese(III)-Mediated Selective Cascade Phosphorylation-Cyclization of Tertiary Enamides for the Synthesis of Multi-Substituted 3-Phosphorylpyridines
The Journal of Organic Chemistry Cite this: J. Org. Chem. 2025, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
Surgical management of anterior urethral stricture: a 23-year single-c
Back to Journals » Research and Reports in Urology » Volume 17 Authors Guo Y, Ma N, Zhang J, Chen S, Liu P, Yang Z, Li Y Received 18 November 2024 Accepted for publication 4 February 2025 Published 19 February 2025 Volume 2025:17 Pages 31—42 DOI https://doi.org/10.2147/RRU.S507169 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Guglielmo Mantica Yilong Guo,1,* Ning Ma,2,* Jiaxiong Zhang,3 Sen Chen,2...
C(sp2)‐Arylsulfones Directly from Arylsulfonyl Chlorides with Boronic Acids by Photoactivation of Boosted EDA Complexes
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Acellular Dermal Matrix Hydrogel Promotes Healing of Radiation-Induced Skin Injury in a Rat Model
Acellular Dermal Matrix Hydrogel Promotes Healing of Radiation-Induced Skin Injury in a Rat Model Background: Radiation-induced skin injury (RISI) is a common complication of radiotherapy, affecting 85-95% of patients. Current treatments lack sufficient evidence of efficacy. Acellular dermal matrix (ADM) hydrogels have shown promise in treating chronic wounds, burns, and ulcers, but their potential in RISI remains unexplored.
The Effect of Construction Workers’ Work Resilience on Their Leisure Sports Participation: The Mediating Role of Safety and Health Awareness
1. Introduction As an important part of blue-collar laborers, the promotion of the well-being of construction workers is a responsibility that cannot be ignored in the development of society. As builders and maintainers of urban infrastructure, the health and safety of the construction worker group is directly related to the stability and development of the whole society [1].
Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion
Abstract The TMPRSS2:ERG gene fusion (T:E fusion) in prostate adenocarcinoma (PCa) puts ERG under the androgen receptor (AR) regulated expression of TMPRSS2. The T:E fusion is frequently associated with PTEN loss, and is highly correlated with decreased expression of INPP4B, both of which may compensate for ERG-mediated suppression of PI3K/AKT signaling.
Electric-Thermal Analysis of Power Supply Module in Graphitization Furnace
1. Introduction Due to its outstanding advantages of high energy density, high power density, long cycle life, and environmental friendliness, lithium-ion batteries have been widely applied in digital products, electric tools, transportation, and power energy storage facilities, driving the vigorous development of upstream and downstream industries [1,2,3,4,5,6,7].
Buildings | Free Full-Text | Exploring Gentrification Architecture Pursuit in Individuals with Childhood Left-behind Experiences-Empirical Analysis Based on the Perspective of Sports Participation
1. Introduction Gentrification is a common phenomenon in today’s society, especially in the field of urban renewal and construction [1].
Identification of the Key Gene DfCCoAOMT1 through Comparative Analysis of Lignification in Dendrocalamus farinosus XK4 and ZPX Bamboo Shoots during Cold Storage
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Green Skepticism? How Do Chinese College Students Feel about Green Retrofitting of College Sports Stadiums?
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MultiCogniGraph: A multimodal data fusion and graph convolutional network‐based multi‐hop reasoning method for large equipment fault diagnosis
REFERENCES 1, . Interpretable fault diagnosis for cyberphysical systems: a learning perspective. Computer. 2021; 54(9): 30-38. 2, . A reinforcement learning system for fault detection and diagnosis in mechatronic systems. Comput Mod Eng Sci. 2020; 124(3): 1119-1130. 3, , , , , . A novel method based on UNET for bearing fault diagnosis. CMC – Comput Mater Cont. 2021; 69(1): 393-408. 4, , , et al. A system fault diagnosis method with a reclustering algorithm. Sci Program. 2021; 2021:6617882. 5.
Liquid-metal-based magnetic fluids - Nature Reviews Materials
Abstract Magnetic fluids, suspensions of magnetic particles in carrier liquids like water, oil or organic solvents, combine magnetic properties with fluidity to achieve features such as rapid magnetic response, reversible viscosity, and tunable thermal and optical properties. However, these carriers tend to have low densities and boiling points, affecting the suspension stability and working temperature range of magnetic fluids.
Antimicrobial Peptide‐Modified Liquid Metal Nanomaterials for Enhanced Antibacterial Photothermal Therapy
Conflict of Interest The authors declare no conflict of interest. References 1 , Chem. Biol. 2000, 7, R127. 2 , , ACS Infect. Dis. 2020, 6, 1346. 3 , , , , , Chem. Soc. Rev. 2012, 41, 3193. 4 , , , , , , , , , ACS Nano 2017, 11, 9330. 5 , , , , , , J. Controlled Release 2020, 328, 251. 6 , , , , , ACS Nano 2013, 7, 1281. 7 , , , , , , , , , ACS Appl. Mater. Interfaces 2019, 11, 26581. 8 , , , , , , , ACS Appl. Mater. Interfaces 2017, 9, 30470. 9 , , , , , , J. Hazard. Mater. 2018, 342, 121. 10 , , , Small 2009, 5, 51.
Precise Construction of Nitrogen‐Enriched Porous Ionic Polymers as Highly Efficient Sulfur Dioxide Adsorbent
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202400746-sup-0001-SuppMat.pdf1.2 MB Supporting Information References 1a) , , , Chem. Soc. Rev. 2016, 45, 6627; b) , , , Prog. Polym. Sci. 2018, 79, 121; c) , , , , , , , , Angew. Chem., Int. Ed. 2024, 63, e202316375; d) , , , , , , , , , , , Adv. Mater. 2023, 35, 2302525. 2a) , , , , , , Chem. Soc. Rev. 2022, 51, 237; b) , , , , , , , , , , , , Nat. Commun. 2023, 14, 263; c) , , , , , Coord. Chem.
HMGB1 prefers to interact with structural RNAs and regulates rRNA methylation modification and translation in HeLa cells - BMC Genomics
To establish an effective cell model to study HMGB1 binding and regulatory targets in cancer cells, we overexpressed the Flag-tagged HMGB1 using a vector-based expression system in HeLa cells, and the Flag-only plasmid as control (Ctrl). The efficacy of Flag-HMGB1 overexpression (HMGB1-OE) was assessed by RT-qPCR and Western blot (Fig. 1A-B, Fig. S1A). Meanwhile, we performed immune fluorescence experiment to check the subcellular localization of HMGB1 in HeLa cells.
Sampled‐data‐based disturbance compensation distributed optimization control for a class of multi‐agent systems
CONFLICT OF INTEREST STATEMENT The authors declare no potential conflict of interests. REFERENCES 1, , , , . Demand-side management via distributed energy generation and storage optimization. IEEE Trans Smart Grid. 2013; 4(2): 866-876. 2, , . Demand-side management using a distributed initialisation-free optimisation in a smart grid. IET Renew Power Gener. 2019; 13(9): 1533-1543. 3, , , . Distributed projection-based algorithms for source localization in wireless sensor networks. IEEE Trans Wirel Commun.
Lercanidipine’s Antioxidative Effect Prevents Noise-Induced Hearing Loss
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
The Multilevel Chain Mediating Mechanism of College Faculty’s Felt Responsibility on Students’ Engagement in Green Building Learning
1. Introduction Since the dawn of the 21st century, a growing awareness among nations globally has emerged regarding the critical importance of enhancing the quality of higher education. University educators, as the primary drivers of students’ academic experiences, play a crucial role in fostering comprehensive human capital development and nurturing a new generation of skilled talents [1,2].
Buildings | Free Full-Text | Exploring the Mechanisms Influencing Users’ Willingness to Pay for Green Real Estate Projects in Asia Based on Technology Acceptance Modeling Theory
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LeGO-LOAM-FN: An Improved Simultaneous Localization and Mapping Method Fusing LeGO-LOAM, Faster_GICP and NDT in Complex Orchard Environments
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Synthesis of Pyrido‐[2,1‐a]isoquinoline Derivatives via Gold(I)‐Catalyzed Intramolecular Cascade Reaction of Enamides
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description adsc202300908-sup-0001-misc_information.pdf9.6 MB Supporting Information References 1 1aG. A.
Genotypic and Allelic Frequencies of GJB2 Variants and Features of Hearing Phenotypes in the Chinese Population of the Dongfeng-Tongji Cohort
1. Introduction Hearing loss is a common sensory disorder affecting more than 1.5 billion people worldwide, including 430 million with moderate or severe hearing loss [1,2]. Hereditary factors or predispositions account for approximately 50% of hearing loss [3,4]. Genetic hearing loss includes syndromic and non-syndromic types, with marked genetic heterogeneity [5,6]. Of the genetic cases, about 70% are non-syndromic deafness, of which around 80% are inherited as an autosomal recessive trait [4].
Metallic Materials for Bone Repair
Repair of large bone defects caused by trauma or disease poses significant clinical challenges. Extensive research has focused on metallic materials for bone repair because of their favorable mechanical properties, biocompatibility, and manufacturing processes. Traditional metallic materials, such as stainless steel and titanium alloys, are widely used in clinics.
Buildings | Free Full-Text | Green Building Consumption Perception and Its Impact on Fitness Service Purchasing Intentions: An Extended Institutional Analysis and Development Decision-Making Model Analysis
2. Literature Review and Research Hypotheses 2.1. Green Building Consumption Perceptions and Willingness to Purchase Fitness Services Cognitive theory suggests that the degree of cognition plays an important role in the formation of behavioral willingness.
Degradation of cochlear Connexin26 accelerate the development of age‐related hearing loss
ABR auditory brainstem response ARHL age-related hearing loss Cx26 Connexin26 DCs deiters' cells Dyn2 dynamin 2 ER endoplasmic reticulum GJPs gap junction plaques GO glucose oxidase GWAS genome-wide association studies IHC inner hair cell OHCs outer hair cells 1 INTRODUCTION With the increased aging of the global population, the prevalence of age-related diseases continues to rise.
[2308.05014] A Comprehensive Empirical Study of Bugs in Open-Source Federated Learning Frameworks
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A Photothermally Enhanced Vancomycin-Coated Liquid Metal Antimicrobial Agent with Targeting Capability
3. Results and Discussion The dispersion of LM into nanodroplets offers advantages in terms of increasing its contact area with bacteria, thereby achieving better bactericidal effects. In this study, ultrasound was used to disperse LM. The structural composition of the antimicrobial nanomaterial system is depicted in a, illustrating that the nanomaterial system consists of a core made of liquid metal and a shell made of Van.
Expansion Technique for Reconstruction of Craniofacial Defect after Plexiform Neurofibroma Excision
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In Situ Fabricated Liquid Metal Capacitors for Plant Sensing
Abstract : Capacitive sensors are essential to promoting modernization and intelligence in agriculture. With the continuous advancement of this sensor technology, the demand for materials with high conductivity and flexibility is rapidly increasing. Herein, we introduce liquid metal as a solution for the in-site fabrication of high-performance capacitive sensors for plant sensing.
Association between carotid ultrasonographic parameters and microvascular and macrovascular complications in diabetes: A systematic review and meta-analysis - PubMed
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In situ observation of crystal rotation in Ni-based superalloy during additive manufacturing process - Nature Communications
Microstructure characterisation A LEICA DMC 4500 optical microscope was adopted to characterise the microstructure of the remelted sample, which was etched by a mixture solution of 100 ml HCl + 100 ml C2H2OH + 50 g CuCl2. A JEOL JSM7100 scanning electron microscope was used to conduct electron backscattered diffraction analysis (the step size was 3 μm).
A Stable 2D Luminescent Metal-Organic Framework as Highly Sensitive Sensor for Fe3+ and Cr2O72−/CrO42− in Water
A Stable 2D Luminescent Metal-Organic Framework as Highly Sensitive Sensor for Fe3+ and Cr2O72−/CrO42− in Water Shigang Ning, Bingcheng Yan, Junrong Wu, Sen Chen, Weipeng Chen, Hongju Tian and Shaowei Zhang Abstract By reacting N,Nʹ-bis(3,5-dicarboxyphenyl)oxalamide (H4BDPO) with d10 electronic configuration Cd2+ ion under solvothermal conditions to produce a two-dimensional (2D) metal-organic framework (MOF), {[Cd3(HBDPO)2(H2O)7]·4H2O}n (1), which has been further characterized by different...
Cells | Free Full-Text | C/EBPβ Coupled with E2F2 Promoted the Proliferation of hESC-Derived Hepatocytes through Direct Binding to the Promoter Regions of Cell-Cycle-Related Genes
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Dynamic Leakage‐Free Liquid Metals
Abstract Leakage is a significant issue that prevents the widespread application of liquid metals (LMs) and an effective solution has not yet been developed. One potential solution is to use the high surface tension of LMs to encapsulate them in a porous material. However, it is challenging as it is difficult to infuse LMs into tiny pores. This study proposes a bottom-up strategy where LMs are doped with NdFeB@Ag particles, which are then magnetized to form a tight porous structure.
Cells | Free Full-Text | Hepatic Polarized Differentiation Promoted the Maturity and Liver Function of Human Embryonic Stem Cell-Derived Hepatocytes via Activating Hippo and AMPK Signaling Pathways
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Design of an Adaptive Distributed Drive Control Strategy for a Wheel-Side Rear-Drive Electric Bus
Abstract : A wheel motor simplifies the chassis structure of an electric bus, greatly improving its response speed and controllability. How to improve the lateral stability of the vehicle under complex and changeable driving conditions is a major problem in the motion control of electric buses. This study proposed an adaptive distributed drive control strategy for a rear-wheel drive electric bus.
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