Seojin Park

Abstract The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals transmitted to the brain. The mechanoelectrical transducer (MET) channel is the entryway for the sound-balance-brain interface, but the channel-complex composition is not entirely known. Here, we report that the mouse utilizes Piezo1 (Pz1) and Piezo2 (Pz2) isoforms as MET-complex components.

AngII angiotensin II Ca2+ calcium ion CSK cytoskeleton ECM extracellular matrix EMD empirical mode decomposition F-actin actin filaments GO gene oncology HHT Hilbert-Huang transform IMFs intrinsic mode functions KEGG Kyoto encyclopedia of genes and genomes NF-κB nuclear factor-κB PDMS polydimethylsiloxane qRT-qPCR quantitative reverse transcription PCR RGD Arg-Gly-Asp scRNA-seq single-cell RNA sequencing SM-MHC smooth muscle myosin heavy chain UMAP uniform manifold approximation and...

Abstract Hearing loss is the most common form of sensory deficit. It occurs predominantly due to hair cell (HC) loss. Mammalian HCs are terminally differentiated by birth, making HC loss incurable. Here, we show the pharmacogenetic downregulation of Cldn9, a tight junction protein, generates robust supernumerary inner HCs (IHCs) in mice.