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Seona Yoon on Muck Rack

Seona Yoon

As seen in: Nature
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Articles

A refined MASH–HCC model identifies macrophage Gadd45b as a key orchestrator of inflammation-driven neoplastic progression Original

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By Hyunmi Kim, Gyeonghun Kim, Sang Lee, Seung Yeon Oh, Jiwoo Kim, Hyun-Ju Park, Eun-Woo Lee, Baek-Soo Han, Chul-Ho Lee, Il Yong Kim, Kwang-Hee Bae, Murim Choi, Je Kyung Seong, Kyoung-Jin Oh, Hyojin Yeon, Da-Yeon Yang, Seona Yoon, Juyong Choi
| Nature Verified
Abstract Metabolic dysfunction-associated steatohepatitis (MASH) is emerging as a leading driver of hepatocellular carcinoma (HCC), yet the molecular mechanisms linking metabolic stress, chronic inflammation and tumorigenesis remain poorly understood. Here we established a metabolically relevant, time-efficient MASH-to-HCC model in C57BL/6N mice by combining a MASH diet with controlled CCl4 administration, enabling stepwise recapitulation of MASH-associated neoplastic progression.
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