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Serdar E Bulun on Muck Rack

Serdar E Bulun

As seen in: Nature, MDPI, Healio, American Journal of Physiology, The Journal of Clinical Investigation, Journal of Molecular Endocrinology, Fertility and Sterility, American Journal of Obstetrics and Gynecology
OB/GYN & REI MD. @NorthwesternMed @NUFeinbergMed Follow me to learn about #WomensHealth related topics including to #endometriosis & #FibroidFriday
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Articles

Endometriosis and ovulatory menstruation: beyond the Sampson principle

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By Serdar E Bulun
| The Journal of Clinical Investigation
Summary of molecular advances and future therapeutic targets Pelvic endometriotic tissue evidently originates from shed endometrial fragments that travel in a retrograde manner primarily through the tubes (19, 20, 45).
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Uterine fibroids

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By Serdar E Bulun, Ping Yin, Jianjun Wei, Azna Zuberi
| American Journal of Physiology Verified
Uterine leiomyomas (also known as fibroids) are the most common tumors in women and those assigned female at birth (1, 2). Millions of reproductive-age women are diagnosed with uterine fibroids annually and experience heavy menstrual bleeding, anemia, pregnancy loss, and other consequences.
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Therapeutic targeting of the tryptophan-kynurenine-aryl hydrocarbon receptor pathway with apigenin in MED12-mutant leiomyoma cells - Cancer Gene Therapy

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By Takashi Iizuka, Helen Shinru Wei, Kadir Buyukcelebi, Mazhar Adli, Serdar E Bulun
| Nature Verified
Abstract Approximately 77.4% of uterine leiomyomas carry MED12 gene mutations (mut-MED12), which are specifically associated with strikingly upregulated expression and activity of the tryptophan 2,3-dioxygenase (TDO2) enzyme, leading to increased conversion of tryptophan to kynureine. Kynurenine increases leiomyoma cell survival by activating the aryl hydrocarbon receptor (AHR).
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