Sergei Maslov on Muck Rack

Sergei Maslov

Urbana
As seen in: Nature, PLOS, MDPI, PNAS, Physical Review Letters, eLife
Professor of Bioengineering and Physics at the University of Illinois, Urbana-Champaign working on genomics, evolution, systems biology, and complex networks
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Articles

Coarse-grained model of serial dilution dynamics in synthetic human gut microbiome

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By Tarun Mahajan, Sergei Maslov
| PLOS
Citation: Mahajan T, Maslov S (2025) Coarse-grained model of serial dilution dynamics in synthetic human gut microbiome. PLoS Comput Biol 21(7): e1013222. https://doi.org/10.1371/journal.pcbi.1013222 Editor: Nic Vega, Emory University Department of Biology, UNITED STATES OF AMERICA Received: March 26, 2024; Accepted: June 10, 2025; Published: July 14, 2025 Copyright: © 2025 Mahajan, Maslov.
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Fitness advantage of sequential metabolic strategies emerges from community interactions in strongly fluctuating environments

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By Zihan Wang, Yu Fu, Akshit Goyal, Sergei Maslov
| biorxiv.org
Abstract Microbes growing in fluctuating environments employ two key metabolic strategies: sequential (diauxic) utilization and co-utilization of nutrients. Most work has focused on understanding and comparing these strategies physiologically for the growth of single species, rather than ecologically for the assembly of complex natural communities. This is in part because of the lack of good metrics quantifying the fitness of different metabolic strategies in ecological contexts.
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SPLICER: a highly efficient base editing toolbox that enables in vivo therapeutic exon skipping - Nature Communications

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By Ananthan Nambiar, Sergei Maslov, Thomas Gaj, Alejandra Zeballos
| Nature
Abstract Exon skipping technologies enable exclusion of targeted exons from mature mRNA transcripts, which have broad applications in medicine and biotechnology. Existing techniques including antisense oligonucleotides, targetable nucleases, and base editors, while effective for specific applications, remain hindered by transient effects, genotoxicity, and inconsistent exon skipping.
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