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Shaela Fields

As seen in: Nature, Science Magazine
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Articles by Shaela Fields

MBNL1 hijacks a structured single-stranded distal DNA element to sustain FLT3 expression in KMT2A-rearranged leukemias

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By Xin Yang, Jiaming Cao, Holly V. Moeller, Meixia Che, Shaela Fields, Siqi Yi, Judith Hyle, Mengli Zhang, Beisi Xu, Yong Cheng, Peng Xu, Yajun Jiang, Chunliang Li
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The molecular mechanisms by which KMT2A-rearranged (KMT2A-r) leukemias maintain the oncogenic FLT3 expression remain largely unclear, limiting therapeutic opportunities.
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Rbm5 sustains leukemia stem cells through a Myc-driven transcriptional circuitry

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By Mengli Zhang, Qiong Zhang, Yuxin Ouyang, Ye Xin, Jianxiang Zhang, Hong liu, Jianfeng Shen, Beisi Xu, Jia Chen, Depei Wu, Chunliang Li, Peng Xu, Shaela Fields
| Nature Verified
Abstract Acute myeloid leukemia (AML) represents a type of malignant hematological disease that is usually caused by the dysregulated developmental program of leukemia stem cells (LSCs). Here, we report that an unappreciated RNA-binding protein, Rbm5, selectively promotes murine leukemogenesis, maintains LSC self-renewal in vivo, and is dispensable for normal hematopoiesis.
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