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Shahsavand Ananloo on Muck Rack

Shahsavand Ananloo

As seen in: British Journal of Cancer, Nature
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Articles

The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus

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By Shahsavand Ananloo, Jr. P. H, Yasin Wayhs, Tannhauser Barros
| Nature Verified
This study was initiated with the objective of evaluating the role of TSPO and allopregnanolone biosynthesis in the treatment of depression in T2DM. Antidepressant-like pharmacological profile of AC-5216 was determined by animal behavioral tests. Based on the data above, the antidepressant-like activities were produced by AC-5216 in HFD-STZ rats and these effects were antagonized by TSPO antagonist PK11195 without affecting the locomotor activity.
Open in Who Shared Issue with article?

Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model

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By Sudip Mondal, Caceres Ide, Shahsavand Ananloo, Evan Hegarty
| British Journal of Cancer Verified
To achieve high-resolution and high-throughput imaging, we developed a large-scale microfluidic chip for immobilization of a large number of C. elegans in a rapid and robust manner. The final design used a single layer microfluidic approach with eight carefully developed unique features: (1) A three-step tapered channel geometry designed to control the aspect ratio for immobilizing day 3 (D3) adult animals in the desired lateral orientation.
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