Shai Kaluski on Muck Rack

Shai Kaluski

As seen in: Cell Reports
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Articles

SIRT6 is a key regulator of mitochondrial function in the brain

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By Dmitrii Smirnov, Ekaterina Eremenko, Daniel Stein, Shai Kaluski
| biorxiv.org
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SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis

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By Miguel Portillo, Shai Kaluski, Ekaterina Eremenko, Alfredo Garcia-Venzor
| Cell Reports Verified
Highlights • DNA damage or SIRT6 absence leads to acetylation of Tau-K174 via CBP • Tau174ac shuttles to the nucleus, where it induces nucleolar activation • SIRT6 regulates Tau-174ac nuclear functions through its deacetylation • Tau174Q increases nucleolar activity and protein synthesis, leading to ATP depletion Summary Several neurodegenerative diseases present Tau accumulation as the main pathological marker.
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By Daniel Stein, Lei Zhong, Uwe Ueberham, Raul Mostoslavsky, Amar Sahay, Shai Kaluski, Miguel Portillo, Antoine Besnard, Monica Einav, Thomas Arendt, Debra Toiber
| secure.jbs.elsevierhealth.com
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