Shalin H. Naik

Keywords clonal barcoding epiblast phylogenetics pedigree lineage tracing Cre embryogenesis cell fate mathematical modeling Get full text access Log in, subscribe or purchase for full access. References 1. Lawson, K.A. ∙ Meneses, J.J. ∙ Pedersen, R.A. Clonal analysis of epiblast fate during germ layer formation in the mouse embryo Development. 1991; 113:891-911 2. Tam, P.P. ∙ Behringer, R.R. Mouse gastrulation: the formation of a mammalian body plan Mech. Dev. 1997; 68:3-25 3. Thomas, P.

Abstract Intratumoural heterogeneity is associated with poor outcomes in breast cancer. To understand how malignant clones survive and grow in metastatic niches, in vivo models using cell lines and patient-derived xenografts (PDX) have become the gold standard.

Confusion exists as to whether transitional dendritic cells are a bone fide subset or just a transitional state, as the name indicates. New data are complicating matters further by showing some interesting heterogeneity in these cells. Dendritic cells (DCs) can be divided into at least three major subsets that are conserved between mice and humans: type 1 conventional DCs (cDC1s); type 2 cDCs (cDC2s); and plasmacytoid DCs (pDCs).