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Shangrui Rao on Muck Rack

Shangrui Rao

As seen in: Nature
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Articles

SH3GLB1 mediates tumor cell resistance to tyrosine kinase inhibitors by regulating mitophagy

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By Jianhua Lü, Hongzheng Li, Shengsheng Zhao, Ji Lin, Bingzi Zhu, Letian Meng, Weiteng Zhang, Yongdong Yi, Danna Liang, Letian Chen, Gongting Zhou, Binglong Bai, Zhonglin Ni, Yuekai Cui, Hongbo Zhang, Xiangyang Xue, Xian Shen, Qiantong Dong, Zhaoyu Shen, Jessica M. Rosenholm, Shangrui Rao, Weijian Sun, Kongqin Lu, Xiaojiao Ruan, Ruan Yu, Luchen Sun
| Nature Verified
Abstract Tyrosine kinase inhibitors (TKIs) have been widely utilized in cancer treatment, but their effectiveness was often hampered by the development of drug resistance. A better understanding of the TKIs resistance mechanism is beneficial to improving therapeutic strategies. Our study found that SH3GLB1 expression was elevated in drug-resistant cells by transcriptome sequencing and correlated with poor prognosis. Silencing SH3GLB1 substantially abrogated TKIs resistance in tumor cells.
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Primary Human Gastric Cancer Cells Integrated Hydrogel Microcapsules for Personalized Drug Screening

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By Lu Fan, Hongzheng Li, Letian Meng, Shangrui Rao
| dx.doi.org
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