Shannon Thomson on Muck Rack

Shannon Thomson

As seen in: Otago Daily Times, Wiley Online Library, MDPI, New Zealand Herald, Radio New Zealand (RNZ), Southern Rural Life, Texas Medical Center, Mountain Scene, The Bharat Express News, Allied Press Limited, The Oamaru Mail and
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Articles

"Blood-Based Transcriptomic Biomarkers Are Predictive of Neurodegenerat" by Artur Shvetcov, Shannon Thomson et al.

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By Artur Shvetcov, Shannon Thomson, Jessica Spathos, Ann-Na Cho
| Texas Medical Center
Abstract Alzheimer's disease (AD) is a growing global health crisis affecting millions and incurring substantial economic costs. However, clinical diagnosis remains challenging, with misdiagnoses and underdiagnoses being prevalent. There is an increased focus on putative, blood-based biomarkers that may be useful for the diagnosis as well as early detection of AD.
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A Systematic Review of the Neuroprotective Role and Biomarker Potential of GDF15 in Neurodegeneration

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By Shannon Thomson, John Cueto, Jessica Spathos, Finula I Isik
| biorxiv.org
Abstract Neurodegeneration is characteristically multifaceted, with limited therapeutic options. One of the chief pathophysiological mechanisms driving these conditions is neuroinflammation, prompting increasing clinical interest in immunomodulatory agents. Growth differentiation factor 15 (GDF15; previously also called macrophage inhibitory cytokine-1 or MIC-1), an anti-inflammatory cytokine with established neurotrophic properties, has emerged as a promising therapeutic agent in recent decades.
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Cerebrospinal fluid proteome profiling using machine learning shows a unique protein signature associated with APOE4 genotype

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By Artur Shvetcov, Shannon Thomson, Ann-Na Cho, Heather Wilkins
| biorxiv.org
Abstract APOE4 is the biggest genetic risk factor for Alzheimers disease (AD). Proteome-wide changes independent of AD brain pathology and whether these extend to APOE4 carriers irrespective of cognitive status remain unknown. To investigate APOE4-associated proteome changes in people with and without AD. Patient clinical, APOE genotype, and cerebrospinal fluid (CSF) proteome data for 735 participants was sourced from the Alzheimers Disease Neuroimaging Initiative (ADNI) database.
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