Shao-Ying Yang
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Enzymatic activity-independent NANS stabilizes LATS2 to drive growth and therapeutic resistance in HR+/HER2- breast cancer
Abstract Hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+ /HER2-) breast cancer is the most common subtype in females, frequently challenged by resistance to endocrine therapy and CDK4/6 inhibitors. Here we show that N-acetylneuraminate synthase (NANS) is significantly upregulated in female HR+ /HER2- breast cancer patients, inversely correlating with patient prognosis.
MYC/TET3‐Regulated TMEM65 Activates OXPHOS‐SERPINB3 Pathway to Promote Progression and Cisplatin Resistance in Triple‐Negative Breast Cancer
1 Introduction Triple-negative breast cancer (TNBC) is a specific subtype of breast cancer, which lacks the expression of estrogen and progesterone receptors and human epidermal growth factor receptor 2 (HER2) and accounts for about 15% of all breast cancer cases.[1] Clinically, TNBC exhibits aggressively clinicopathological features with a high incidence of early recurrence and distant metastases and the worst outcomes.[1] Due to the absence of validated therapeutic targets, chemotherapy is...
Kinesin-like protein KIFC2 stabilizes CDK4 to accelerate growth and confer resistance in HR+/HER2- breast cancer
ResearchCell biologyOncology Open Access | 10.1172/JCI183531 J Clin Invest. https://doi.org/10.1172/JCI183531. Copyright © 2025, Yang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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