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Shaqed Carasso on Muck Rack

Shaqed Carasso

As seen in: Nature, BioRxiv, Cell Host & Microbe
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Articles

Bacteriophage-driven DNA inversions shape bacterial functionality and long-term co-existence in Bacteroides fragilis

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By Shaqed Carasso, Jia Zhang, Haitham Hajjo, Roni Keshet-David
| BioRxiv
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Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota

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By Shaqed Carasso, Rappaport Faculty, Rawan Zaatry, Haitham Hajjo
| Cell Host & Microbe Verified
Highlights • Distinct DNA inversion patterns of Bacteroidales in healthy vs. IBD patients • Inflamed gut induces DNA inversion of the immunomodulatory PSA of B. fragilis • Bacteriophage levels correlate with bacterial DNA inversions in patients • Isolated bacteriophage affects PSA phase variation and Treg levels Summary Reversible genomic DNA inversions control the expression of numerous gut bacterial molecules, but how this impacts disease remains uncertain.
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Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota

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By Shaqed Carasso, Rappaport Faculty, Rawan Zaatry, Haitham Hajjo
| Cell Host & Microbe Verified
Highlights • Distinct DNA inversion patterns of Bacteroidales in healthy vs. IBD patients • Inflamed gut induces DNA inversion of the immunomodulatory PSA of B. fragilis • Bacteriophage levels correlate with bacterial DNA inversions in patients • Isolated bacteriophage affects PSA phase variation and Treg levels Summary Reversible genomic DNA inversions control the expression of numerous gut bacterial molecules, but how this impacts disease remains uncertain.
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