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Sharon B. Cantor on Muck Rack

Sharon B. Cantor

As seen in: Nature, Cell Press
Professor studying DNA replication and role in cancer, chemoresistance, and developmental diseases
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Articles

RAD51 is chromatin enriched and targetable in BRCA1-deficient cells

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By Min Peng, Silviana Lee, Hitha Gopalan Nair, Nathan J MacGilvary, Ke Cong, Michitsura Kraemer, Rui Li, Jill McConnell, Christina E Baer, Bin Deng, Lihua Zhu, Sharon B. Cantor
| Cell Press Verified
Keywords MDC1 53BP1 H2AX BRCA1 gaps HR PARPi TLS RAD51 foci Introduction Cancer cells deficient in the hereditary breast and ovarian cancer genes, BRCA1 or BRCA2 (BRCA), are hypersensitive to poly (ADP-ribose) polymerase inhibitors (PARPi).
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Unveiling the toxicity of single-stranded DNA gaps through a yeast model - Nature Structural & Molecular Biology

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By Sharon B. Cantor
| Nature Verified
A study on a yeast model explores how ssDNA gaps induce cell death and genomic instability, implicating Rad9 and Rad51 in gap repair and protection. Gaps forming secondary structures trigger chromosome fragility, deletions, rearrangements, or cell death pathways, showing how gaps are a vulnerability in cancer cells with opportunity for selective targeting.
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Exploiting replication gaps for cancer therapy

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By Ke Cong, Sharon B. Cantor
| Cell Press Verified
• None The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer. : • None Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers. : • None RNA:DNA hybrids from Okazaki fragment are cis-regulators of Ku function in safeguarding replication fork integrity.
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