Sharon R Garrott on Muck Rack

Sharon R Garrott

As seen in: Cell Press
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Articles

Synthetic cargo adaptors reveal molecular features that can enhance dynein activation

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By Aravintha Siva, John Gillies, Sharon R Garrott, Ashley de Borchgrave
| biorxiv.org
Abstract Cytoplasmic dynein-1 (dynein) is the primary retrograde-directed microtubule motor in most eukaryotes. To be active, dynein must bind to the dynactin complex and a cargo-specific adaptor to form the active transport complex. There are nearly 20 adaptors that, despite having low sequence identity, all contain two discrete domains that mediate binding to the same regions of dynein and dynactin.
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CryoEM shows the active dynein complex on microtubules

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By Sharon R Garrott, Morgan E. DeSantis
| Cell Press Verified
In a recent study, Chaaban and Carter use cryo-electron microscopy (cryo-EM) and an innovative data-processing pipeline to determine the first high-resolution structure of the dynein–dynactin–BICDR1 complex assembled on microtubules. The structure of the complex reveals novel stoichiometry and provides new mechanistic insight into dynein function and mechanism.
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Ndel1 modulates dynein activation in two distinct ways

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By John Gillies, Sharon R Garrott, Aravintha Siva, Rita El Jbeily
| biorxiv.org
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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