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Sharujan Suthakaran on Muck Rack

Sharujan Suthakaran

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Articles

Epigenetic modulation of stromal cell states underpins pathological tissue niches in Crohn’s disease

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By Simon Koplev, Osheen Sharma, Simon Woelfel, Ni Huang, Mathilde Pohin, Adrian Feile, Mikel Rezola Artero, Ioannis Sarropoulos, J. Patrick Pett, Julia Nyman, Tom Thomas, Duy Thanh Pham, Duy Phạm, Moustafa Attar, Julia Pakpoor, Alistair Easton, Matt Butler, James Dunford, Martin Philpott, Mark Coles, Christopher Buckley, Calliope A Dendrou, Lorenz Kretschmer, Lisa M Dratva, Fadi Issa, Joanna Hester, Jens Rittscher, Alissa Walsh, Simon P. Travis, Fränze Progatzky, Lukas Unger, Katherine Baker, Bruce George, Hussein Al-Mossawi, Paul Klenerman, Alexander Mosig, Udo Oppermann, Sarah A Teichmann, Fiona Powrie, Matthias G. Friedrich, Maria Warschinke, Sharujan Suthakaran, Kate Milosevic-Hutton, Khalid Shamiyah
| Nature Verified
Abstract Stromal cell states are altered in active Crohn’s disease (CD), but their origin and phenotypic stability are unknown. Using single-cell spatial transcriptomics, RNA sequencing and ATAC sequencing of ~2,500,000 cells, we map 18 distinct stromal cell states within their cellular and cytokine signaling environments in human full-thickness CD bowel.
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