Sharyn A. Endow on Muck Rack

Sharyn A. Endow

United States
As seen in: Cell Press
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Articles

Mechanical states of a motor protein in the spindle

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By Kevin K. Do, Ian Greear, Umika Paul, Neil Billington, Zimiao Meng, Matthew Wang, Rong Liu, Brenton D. Hoffman, Sharyn A. Endow
| Cell Press Verified
Keywords spindle mechanics load-bearing motor protein microtubule crosslinking microtubule sliding resisting forces motor force production osmotic shock FRET tension sensor spindle assembly kinesin-14 Introduction During division, spindles assemble and chromosomes undergo movements driven by forces in the cell. The forces required for division are thought to be produced by microtubule dynamics—rapid polymerization and depolymerization of spindle microtubules—and microtubule motor proteins.
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