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Shaunik Sharma

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Articles

Neuroprotective Effects of Naltrexone in a Mouse Model of Post-Traumatic Epilepsy

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By Saúl Rodríguez, Zeru Peterson, Shaunik Sharma, Grant Tiarks
| BioRxiv
Abstract Traumatic Brain Injury (TBI) induces neuroinflammatory responses that can initiate epileptogenesis, which develops into epilepsy. Recently, we identified the anti-convulsive effects of naltrexone, a mu-opioid receptor (MOR) antagonist. While blocking opioid receptors can reduce inflammation, it is unclear if post-TBI epileptogenesis can be prevented by blocking MORs. Here, we tested if naltrexone prevents neuroinflammation and epileptogenesis post-TBI.
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