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Articles by Shen chen
Cardiac ventricular Kir6.1 ATP-sensitive potassium channels: an overlooked effector of cardioprotection
Abstract Introduction: Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels are octameric structures, comprising a pore-forming homotetramer of Kir6.1 or Kir6.2, with 4 accessory sulphonylurea receptor (SUR) subunits. The canonical ventricular KATP channel is the highly ATP-sensitive Kir6.2/SUR2A complex, which is largely inactive under normal physiological conditions.
Towards 3D Reconstruction of Multi-Shaped Tunnels Utilizing Mobile Laser Scanning Data
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La Chine appliquera les tarifs douaniers convenus dans un accord de récolte précoce dans le cadre de l'ALE sur certaines importations en provenance du Honduras
La Chine appliquera les tarifs douaniers convenus dans un accord de récolte précoce dans le cadre de l'accord bilatéral de libre-échange signé avec le Honduras sur certaines importations en provenance de ce pays, a annoncé vendredi la Commission des droits de douane du Conseil des Affaires d'Etat. Les tarifs douaniers entreront en vigueur le 1er septembre 2024.
La Chine crée un fonds pour soutenir le Programme des forêts-refuges des Trois régions du nord
La Chine a créé un fonds spécial pour offrir un soutien financier au Programme des forêts-refuges des Trois régions du nord, un grand projet de reboisement dans le nord-est, le nord et le nord-ouest du pays, dans le cadre de ses efforts continus pour lutter contre la désertification et restaurer l'environnement écologique, selon un communiqué publié lundi.
Identification and characterisation of functional K
APD action potential duration APD90 action potential to 90% repolarised CiPA Comprehensive in vitro Proarrhythmia Assay KATP Channel ATP sensitive potassium channel KCNJ8 KD KCNJ8 (Kir6.1) knockdown SUR sulfonylurea receptor 1 What is already known The accepted view is that highly ATP-sensitive Kir6.2/SUR2A (KATP) channels functionally dominate in ventricular cardiomyocytes. Due to their ATP sensitivity, cardiac Kir6.2/SUR2A channels cannot open until catastrophic intracellular ATP depletion.
Improvement of Post-Surgery Constipation in Patients with Fractures by Lactobacillus rhamnosus JYLR-127: A Single-Blind Randomized Controlled Trial
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Effect of Temperature and NaClO on the Corrosion Behavior of Copper in Synthetic Tap Water
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Analysis of Ethylene Signal Regulating Sucrose Metabolism in Strawberry Fruits Based on RNA-seq
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
PD‐L1 inhibitors combined with whole brain radiotherapy in patients with small cell lung cancer brain metastases: Real‐world evidence
1 INTRODUCTION Small cell lung cancer (SCLC) is a malignant and aggressive tumor originating from the mucous membrane of the lungs or from the gland.1 Patients with SCLC often have poor clinical outcomes due to the high risk of the cancer spreading to the brain.
Effects of Supplemental Lighting on Flavonoid and Anthocyanin Biosynthesis in Strawberry Flesh Revealed via Metabolome and Transcriptome Co-Analysis
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
A study on the influencing factors of corporate digital transformation: empirical evidence from Chinese listed companies - Scientific Reports
Abstract In an era where digital technology is reshaping business landscapes, understanding the factors that drive corporate digital transformation is essential. In this paper we explore these influencing factors, focusing on Chinese A-share listed companies from 2007 to 2021. Our approach involved a comprehensive analysis of multiple variables through regression techniques to determine their impact on digital transformation.
Rational construction of micro-plate-like iron oxide/aluminium oxide-fabricated screen-printed carbon electrode for the electrochemical detection of the antiandrogen drug
Rational construction of micro-plate-like iron oxide/aluminium oxide-fabricated screen-printed carbon electrode for the electrochemical detection of the antiandrogen drug† As the rate of prostate cancer is increasing, the strategies and challenges for its treatment are attracting significant attention. In this case, nilutamide (NTM) is an antiandrogen drug employed for the treatment of prostate cancer; however, its over-usage may induce severe health issues.
La Chine exempte de droit de timbre le commerce offshore dans la zone de libre-échange de Shanghai
Le commerce offshore dans la Zone pilote de libre-échange (Shanghai) de la Chine et sa nouvelle zone de Lingang sera exempté de droit de timbre dans le cadre d'un essai visant à stimuler le développement du commerce offshore.
La Chine alloue 141 millions de yuans pour restaurer la circulation routière dans des provinces touchées par le froid
La Chine a alloué mardi 141 millions de yuans (environ 19,84 millions de dollars) pour restaurer la circulation routière dans les provinces touchées par des catastrophes provoquées par les basses températures, la pluie, la neige et le gel. Les fonds, alloués conjointement par le ministère des Finances et le ministère des Transports, seront versés au Hebei, au Shanxi, au Jiangsu, à l'Anhui, au Shandong, au Henan, au Hunan, au Hubei, au Guizhou, à Chongqing et au Shaanxi.
Prevalence and risk factors associated with dehydration of patients with dysphagia in eastern China: A cross‐sectional study
DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request.
Atomic-scale manipulation of buried graphene–silicon carbide interface by local electric field - Communications Physics
Abstract Precision of scanning tunneling microscopy (STM) enables control of matter at scales of single atoms. However, transition from atomic-scale manipulation strategies to practical devices encounters fundamental problems in protection of the designer structures formed atop the surface. In this context, STM manipulation of subsurface structures on technologically relevant materials is encouraging.
La Chine prolonge l'exemption tarifaire sur certains produits américains
La Chine continuera à exempter certains produits américains de droits de douane supplémentaires jusqu'en juillet 2024, a déclaré vendredi la Commission des tarifs douaniers du Conseil des Affaires d'Etat. Selon un communiqué précédent publié en mai, certains articles en provenance des Etats-Unis ont été exclus des contre-mesures tarifaires contre les mesures de la section 301 des Etats-Unis jusqu'au 31 décembre 2023.
La Chine alloue un fonds d'urgence pour la restauration des routes dans les régions touchées par le séisme
Le gouvernement chinois a alloué mercredi 30 millions de yuans (environ 4,23 millions de dollars) de fonds d'urgence pour la restauration des routes au Gansu et au Qinghai, provinces touchées par le séisme dans le nord-ouest du pays. Le nouveau fonds, débloqué conjointement par le ministère des Finances et le ministère des Transports, aidera les deux provinces à remettre en état les routes touchées par le tremblement de terre survenu lundi soir.
A perspective on the role of physiological stresses in cancer, diabetes and cognitive disease as environmental diseases
1 Introduction Failure of an organism to respond adequately to stimuli, whether originating internally or externally, resulting in the disruption of cellular homeostasis can be classified as stress. Stress may stem from physical, physiological, and psychological sources. Physiological stress primarily occurs when the body faces environmental challenges, which alter normal physiological functionality, which is the focus of this perspective.
Observation Capability Evaluation Model for Flood-Observation-Oriented Satellite Sensor Selection
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Synchronous Superficial Middle Cerebral Vein Outflow Correlates Favorable Tissue Fate After Mechanical Thrombectomy for Acute Ischemic Stroke
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Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Subchronically Exposed to Ambient Particulate Matter | Environmental Health Perspectives | Vol. 131, No. 7
Abstract Background: Chronic lung injury and dysregulated cellular homeostasis in response to particulate matter (PM) exposure are closely associated with adverse health effects. However, an effective intervention for preventing the adverse health effects has not been developed.
A Review of Classification, Biosynthesis, Biological Activities and Potential Applications of Flavonoids
Abstract : Flavonoids represent the main class of plant secondary metabolites and occur in the tissues and organs of various plant species. In plants, flavonoids are involved in many biological processes and in response to various environmental stresses. The consumption of flavonoids has been known to reduce the risk of many chronic diseases due to their antioxidant and free radical scavenging properties.
Determination of flutamide toward a real-time electrochemical sensor based on ultrathin reduced graphene oxide-covered MoW-P
Determination of flutamide toward a real-time electrochemical sensor based on ultrathin reduced graphene oxide-covered MoW-P† The rapid and accurate detection of Flutamide (FLT) is crucial because it is used for the potent prostate cancer treatment, that can cause liver toxicity. Herein, we report the electrochemical detection of FLT in a wide range of concentrations using composite-modified electrode of MoW-P covered by ultrathin-reduced graphene oxide (RGO).
Dual Antagonism of α9α10 nAChR and GABAB Receptor-Coupled CaV2.2 Channels by an Analgesic αO-Conotoxin Analogue
Pain severely affects the physical and mental health of patients. The need to develop nonopioid analgesic drugs to meet medical demands is urgent. In this study, we designed a truncated analogue of αO-conotoxin, named GeX-2, based on disulfide-bond deletion and sequence truncation. GeX-2 retained the potency of its parent peptide at the human α9α10 nAChR and exhibited potent inhibitory activity at CaV2.2 channels via activation of the GABAB receptor (GABABR).
Dual Antagonism of α9α10 nAChR and GABAB Receptor-Coupled CaV2.2 Channels by an Analgesic αO-Conotoxin Analogue
Pain severely affects the physical and mental health of patients. The need to develop nonopioid analgesic drugs to meet medical demands is urgent. In this study, we designed a truncated analogue of αO-conotoxin, named GeX-2, based on disulfide-bond deletion and sequence truncation. GeX-2 retained the potency of its parent peptide at the human α9α10 nAChR and exhibited potent inhibitory activity at CaV2.2 channels via activation of the GABAB receptor (GABABR).
The Global Spread Pattern of Rat Lungworm Based on Mitochondrial Genetics
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Design, synthesis and mechanism of action of novel μ-conotoxin KIIIA analogs for inhibition of the voltage-gated sodium channel Nav1.7
2.1 Analysis of different framework analogs The KIIIA Isomer I contains three disulfide-bonds and its chemical synthesis is difficult and costly. Three first-generation analogs of KIIIA Isomer I, including KIIIA-1, KIIIA-2 and KIIIA-3, were designed by deletion of one of the disulfide-bonds with Ala replacement of the corresponding Cys pairs in the sequence (Table 1). The biological activities and structure stabilities of these three analogs were evaluated.
Comparative Transcriptomic Analysis of Key Genes Involved in Citrinin Biosynthesis in Monascus purpureus
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Chine : les recettes du budget public général dépassent les 20.000 milliards de yuans en 2022
Les recettes du budget public général de la Chine ont augmenté de 0,6% en glissement annuel pour atteindre environ 20.370 milliards de yuans (environ 3.010 milliards de dollars) en 2022, selon des données officielles publiées lundi. En excluant l'impact des remboursements de crédits de la taxe sur la valeur ajoutée, les recettes du budget public général ont augmenté de 9,1% par rapport à 2021, selon le ministère des Finances.
Sustainable EFL Blended Education in Indonesia: Practical Recommendations
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessPerspective by Putri Gayatri 1,2, Helena Sit 2,*, Shen Chen 2 and Hui Li 3 1 Faculty of Agriculture, Universitas Brawijaya, Malang 65145, Indonesia 2 School of Education, The University of Newcastle, Newcastle, NSW 2308, Australia 3 Shanghai Institute of Early Childhood Education, Shanghai Normal University, Shanghai 200234, China * Author to whom correspondence should be addressed.
Biosynthesis of plant-specific alkaloids tetrahydroprotoberberines in engineered Escherichia coli
Biosynthesis of plant-specific alkaloids tetrahydroprotoberberines in engineered Escherichia coli Wanli Zhao, Manyu Liu, Shen Chen, kemeng liu, Hanqing Liu, Chenhui Ou, Wenling Dai, Xiufeng Liu and Jihua Liu Abstract Tetrahydroprotoberberines (THPBs), mainly sourced from the medicinal plants of genus Stephania and Corydalis, exhibit a variety of pharmacological activities.
Synthesis and Characterization of Pyrochlore-Type Praseodymium Stannate Nanoparticles: An Effective Electrocatalyst for Detection of Nitrofurazone Drug in Biological Samples
Apart from perovskites, the development of different types of pyrochlore oxides is highly focused on various electrochemical applications in recent times.
Identification of the novel bacterial blight resistance gene Xa46(t) by mapping and expression analysis of the rice mutant H120
Abstract Rice bacterial leaf blight is caused by Xanthomonas oryzae pv. oryzae (Xoo) and produces substantial losses in rice yields. Resistance breeding is an effective method for controlling bacterial leaf blight disease. The mutant line H120 derived from the japonica line Lijiangxintuanheigu is resistant to all Chinese Xoo races.
FeMn Layered Double Hydroxides: An Efficient Bifunctional Electrocatalyst towards Real-time Tracking of Cysteine in Whole Blood and Dopamine in Biological Samples
FeMn Layered Double Hydroxides: An Efficient Bifunctional Electrocatalyst towards Real-time Tracking of Cysteine in Whole Blood and Dopamine in Biological Samples A peculiar clock-regulated design of FeMn-LDHs (FMH) with specific physiochemical attributes has been developed and employed towards highly sensitive detection of cysteine (CySH) and dopamine (DA). The FMH nanoparticles were synthesized through a facile hydrothermal approach clocked at various (6 h, 12 h and 18 h) operating periods.
Developments on Electrochemical Sensors for Detection of Toxic and Bioactive Molecules
Developments on Electrochemical Sensors for Detection of Toxic and Bioactive Molecules R Ramachandran, Shen Ming Chen, Thangaraj Baskar, Perumal Elumalai, Paulsamy Raja, Tse-Wei Chen, Ramanujam Kannan, Dinakaran Kannaiyan and Gnana Kumar George Abstract Design and development of novel sensitive and cost-effective electrochemical sensors based on various classes of nanocomposite fabricated by different kinds of methods for the detection of biomolecules (glucose, dopamine, ascorbic acid and...
Synthesis, Characterization and Catalytic Performance of Nanostructured Dysprosium Molybdate Catalyst for the Selective Biomolecule Detection in Biological and Pharmaceutical Samples
Synthesis, Characterization and Catalytic Performance of Nanostructured Dysprosium Molybdate Catalyst for the Selective Biomolecule Detection in Biological and Pharmaceutical Samples Raj Karthik, Mutharani Bhuvanenthiran , Shen Ming Chen, J.
Facile, low temperature synthesis of Tungsten carbide (WC) flakes for sensitive and selective electrocatalytic detection of dopamine in biological samples
Facile, low temperature synthesis of Tungsten carbide (WC) flakes for sensitive and selective electrocatalytic detection of dopamine in biological samples Transition metal carbides have shown potential for use in electrochemical applications due to their excellent electronic conductivity, stability and electrocatalysis.
Bimetallic vanadium cobalt diselenides nanosheets with additional active sites for excellent asymmetric pseudocapacitive performance: Compare the electrochemical performances with M-CoSe2 (M = Zn, Mn, and Cu)
Bimetallic vanadium cobalt diselenides nanosheets with additional active sites for excellent asymmetric pseudocapacitive performance: Compare the electrochemical performances with M-CoSe2 (M = Zn, Mn, and Cu) Recently, the bimetallic selenides have been considered as the efficient electrocatalysts towards various electrochemical applications. Here, we demonstrated the synthesis of different transition metals (M = V, Zn, Mn, and Cu) incorporated CoSe2 (M-CoSe2).
Determination of 8-hydroxy-2'-deoxyguanosine oxidative stress biomarker using dysprosium oxide nanoparticles@reduced graphene oxide
8-hydroxy-2’-deoxyguanosine (8-OHdG) is a risk factor with a crucial role in inducing of oxidative stress involved in the physicological processes as well as a biomarker in the response of human diesease and injury. Therefore, the development of a robust, low-cost, and portable analytical tool for quantification of 8-hydroxy-2'-deoxyguanosine in human bloold and urine samples. It is essential to diagnose oxidative stress related diseases in human body.
Hierarchically structured porous RGO nanosheets/CuFe2O4 nanodots composite for sensitive detection of oxidative stress biomarker in biological fluids
In this work, stable and catalytically active copper ferrite nanodots (CuFe2O4) entrapped by porous RGO nanosheets were prepared via a facile condensation process using green reducing agent. The composite was characterized by HR-TEM, EDX, XRD, Raman, TGA, and electrochemical methods.
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CHOICE INT’L FORWARDING CO., LTD was established in 1997, focusing on Middle East and African countries and providing complete one-stop logistics service for customers in countries including Middle East and Africa. Through many years of operation, it has developed into a professional international comprehensive logistics enterprise with transnational operations at present, engaging in Middle East and Africa import and export cargo transportation and logistics services.
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