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Shenbaga Moorthy Balakrishnan on Muck Rack

Shenbaga Moorthy Balakrishnan

As seen in: Cell Press
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Articles

Cross-Linking Mass Spectrometry: Workflow Enhancements for Mapping Large-Scale Interactomes

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By Shenbaga Moorthy Balakrishnan, Taoufik Nedjadi, Hifzur Rahman Ansari, Rawiah Alsiary
| Cell Press Verified
ReviewOnline nowOpen access Affiliations & Notes 1King Abdullah International Medical Research Center, P.O. Box 9515, Jeddah 21423, Saudi Arabia 2King Saud bin Abdulaziz University for Health Sciences, P.O. Box 9515, Jeddah 21423, Saudi Arabia 3Ministry of the National Guard-Health Affairs, P.O. Box 9515, Jeddah 21423, Saudi Arabia Article Info Publication History: Received January 18, 2026; Accepted May 22, 2026; Published online May 26, 2026 DOI: 10.1016/j.bpj.2026.05.033 External LinkAlso...
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Optimizing the Formulation and Lyophilization Process for a Fragment Antigen Binding (Fab) Protein Using Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry (ssHDX-MS) | Molecular Pharmaceutics

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By Lokesh Kumar, Karthik Balakrishna Chandrababu, Shenbaga Moorthy Balakrishnan, Andrea Allmendinger
| American Chemical Society
Solid-state hydrogen–deuterium exchange with mass spectrometry (ssHDX-MS) was evaluated as an analytical method to rapidly screen and select an optimal lyophilized fragment antigen binding protein (Fab) formulation and the optimal lyophilization cycle. ssHDX-MS in lyophilized Fab formulations, varying in stabilizer type and stabilizer/protein ratio, was conducted under controlled humidity and temperature.
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