Shigetoshi Ohshima on Muck Rack

Shigetoshi Ohshima

As seen in: The Journal of Biological Chemistry
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Articles

Toll-like Receptor 4 on Macrophage Promotes the Development of Steatohepatitis-related Hepatocellular Carcinoma in Mice

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By Mitsuaki Ishioka, Shinichiro Minami, Yasuo Horie, Shigetoshi Ohshima, Takashi Goto
| The Journal of Biological Chemistry Verified
The role of Toll-like receptor (TLR) signaling has attracted much attention in the development of hepatic inflammation and hepatocellular carcinoma (HCC). We herein sought to determine the role of TLRs and responsible cells in steatohepatitis-related HCC. We used hepatocyte-specific Pten-deficient (PtenΔhep) mice, which exhibit steatohepatitis followed by liver tumor formation, including HCC.
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