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Shih-Ying Tsai on Muck Rack

Shih-Ying Tsai

As seen in: Cell Reports
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By Kenneth G. Trieu, Shih-Ying Tsai, Markus Eberl, Owen J. Doane, Jamie Peterson, Natalia A. Veniaminova, Marina Grachtchouk, Paul W. Harms, Fredrik J. Swartling, Virginia Ju, Noah C. Ford, Andrzej A. Dlugosz
| Cell Reports Verified
Highlights • Upstream Hh pathway activation is necessary, but not sufficient, for BCCs to progress • Failed nascent tumors become dormant and may spontaneously regress over time • Secondary mutations enable rare tumors to overcome barriers to progression • Increased Mycn promotes BCC progression Summary Basal cell carcinomas (BCCs) frequently possess immense mutational burdens; however, the functional significance of most of these mutations remains unclear.
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