Shila Mekhoubad on Muck Rack

Shila Mekhoubad

As seen in: Science Magazine
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Articles

Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction

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By Zeina Nehme, Yosuke Sakamachi, Peina Wang, Caiwei Guo, Kuchuan Chen, Sarat C. Vatsavayai, Tetsuya Akiyama, Chang Liu, Yi Zeng, Edith Yang, Rasheen Powell, Shannon Zhen, Ryan D. Morrie, Georgiana Miller, Dragana Ilic, Moritz Boll, Euan Parnell, Peter Penzes, Noa Lipstein, Eric Green, Leonard Petrucelli, William W. Seeley, Odilia Sianto, Juliane Bombosch, Shila Mekhoubad
| Science Magazine
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary TAR DNA binding protein 43 (TDP-43) loss of function (LOF) is a critical feature of amyotrophic lateral sclerosis and other neurodegenerative diseases. TDP-43 LOF leads to cryptic exons in certain mRNAs, affecting protein function. Here, Guo et al.
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