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Frontiers | Effectiveness and safety of rituximab monotherapy versus conventional regimens for adult idiopathic membranous nephropathy: real-world retrospective study
Introduction Idiopathic membranous nephropathy (IMN) is a common cause of nephrotic syndrome (NS) in adults. Pathologically, IMN is characterized by subepithelial immune complex deposits, primarily composed of IgG and C3, accompanied by thickening of the glomerular basement membrane. Clinically, IMN is characterized by heavy proteinuria. If left untreated, patients with persistent heavy proteinuria are at risk of progressing to end-stage renal disease (ESRD) (1, 2).
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