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Shiying Wu on Muck Rack

Shiying Wu

As seen in: Nature, Wiley Online Library, Frontiers, MDPI, ACS Publications, Royal Society of Chemistry, Cell Press
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Articles

Associations between artificial light exposure during pregnancy and the risk of gestational diabetes mellitus: a prospective cohort study

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By Shufeng Lin, Shiying Wu, Shuanglong Liu, Jiaxiang Huang, Yaping Xie
| Frontiers
Abstract Background: Gestational diabetes mellitus (GDM), characterized by glucose intolerance first identified during pregnancy, poses significant risks to both maternal and neonatal health. With its prevalence rising globally, GDM has become a critical public health issue. Emerging evidence suggests that environmental factors, such as light exposure, may influence GDM risk.
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‘Tripod-like’ lung-targeting (LuT) lipids for highly efficient and selective LNPs for gene delivery and editing

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By Zeru Tian, Xu Wang, Sumanta Chatterjee, William Miller, Erick Guerrero, Yun-Chieh Sung, Alexis Benítez, Xiaoyan Bian, Amogh Vaidya, Xizhen Lian, Stephen Moore, Yehui Sun, MinJeong Kim, Yufen Xiao, Shiying Wu, Bret M. Evers, Jeon Lee, Lukas Farbiak, Daniel Siegwart, Sean Dilliard
| Nature Verified
Abstract Developing lung-targeting delivery systems is essential for treating pulmonary conditions such as genetic respiratory diseases, infections, fibrosis and cancer. We synthesized and evaluated 444 lung-targeting lipids (LuT lipids) that form lipid nanoparticles (LNPs) to efficiently deliver messenger RNA and CRISPR–Cas9 genome editors to lungs with minimal side effects.
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Dual SORT LNPs for multi-organ base editing - Nature Biotechnology

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By Eunice Song, Yehui Sun, Sang Lee, Shiying Wu
| Nature Verified
Abstract Alpha-1 antitrypsin (A1AT) deficiency (AATD) is caused by a mutation in the SERPINA1 gene (PiZ allele), where misfolded A1AT liver accumulation leads to liver damage, and A1AT deficiency in the lungs results in emphysema due to unregulated neutrophil elastase activity. Base editing offers a potential cure for A1AT; however, effective treatment is hindered by the absence of dual-target delivery systems that can target key tissues.
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