Shobhona Sharma

You are already at the latest version Cerebral Malaria (CM) is a life-threatening disease caused by Plasmodium falciparum. There are currently no reliable tools to predict the progression of cerebral syndromes in humans. Cerebral malaria results in mortality for approximately 1–2% of affected patients, with diagnosis generally established following the onset of neurological manifestations—such as coma, paralysis, or seizures—which may also be indicative of alternative medical conditions.

2.4. 1H NMR Spectroscopy, Assignment, and Quantification of the RBC Metabolome All the spectra were recorded at 298 K. The 1-dimensional 1H NMR spectrum, 2-dimensional J-resolved, and TOCSY spectra were acquired at 298 °K on a Bruker AVANCE-II 700 MHz spectrometer (Bruker Biospin, Karlsruhe, Germany) fitted with a TBI probe. The HMQC spectrum was recorded in a Bruker Avance-II 500 MHz spectrometer fitted with a TXI probe.

The most effective vaccine candidate of malaria is based on the Plasmodium falciparum circumsporozoite protein (CSP), a major surface protein implicated in the structural strength, motility, and immune evasion properties of the infective sporozoites.