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Shobina Premachandran on Muck Rack

Shobina Premachandran

As seen in: Nature, Wiley Online Library, BioRxiv
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Articles

PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection - npj Parkinson's Disease

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By Sherilyn Junelle Recinto, Alexandra Kazanova, Lin Liu, Brendan Cordeiro, Shobina Premachandran, Alexis Allot, Elia Afanasiev, Sriparna Mukherjee, Adam MacDonald, Adam Macdonald, Moein Yaqubi, Heidi M. McBride, Diana Matheoud, Louis-Eric Trudeau, Samantha Gruenheid, Hicham Bessaiah
| Nature Verified
Abstract Parkinson’s disease is characterized by a period of non-motor symptoms, including gastrointestinal dysfunction, preceding motor deficits by several years to decades. This long prodrome is suggestive of peripheral immunity involvement in the initiation of disease. We previously developed a model system in PINK1 KO mice displaying PD-like motor symptoms at late stages following intestinal infections. Herein, we map the initiating immune events at the site of infection in this model.
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A subset of human choroid plexus epithelial cells exhibit mitochondrial eccentricity and distinct expression of the pigmentation-associated enzyme TYRP1

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By Adam MR Groh, Shobina Premachandran, Moein Yaqubi, Finn Creeggan
| BioRxiv
Abstract For decades, ultrastructural evaluation of epithelial cells in diverse organ systems has demonstrated the existence of two subtypes identified by stark differences in cytoplasmic electron density — so-called light and dark epithelial cells. Choroid plexus (CP) epithelial cells are key regulators of CSF homeostasis and are one of many specialized epithelial linings that exhibit this bimodal phenotype.
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Characterizing enteric neurons in dopamine transporter (DAT)‐Cre reporter mice reveals dopaminergic subtypes with dual‐transmitter content

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By Sherilyn Junelle Recinto, Shobina Premachandran, Sriparna Mukherjee, Alexis Allot
| Wiley Online Library Verified
Calcb Calcitonin-gene related peptide Cartpt cocaine- and amphetamine-regulated transcript protein ChAT choline acetyltransferase CMMC colonic migrating motor complexes CNS central nervous system DA dopamine DAT dopamine transporter ENS enteric nervous system FACS fluorescence-activated cell sorting Girk2 G-protein-regulated inward-rectifier potassium 2 Grp gastrin-releasing neuropeptide Htr2b 5-hydroxytryptamine/serotonin receptor 2B LMMP longitudinal muscle myenteric plexus MP myenteric...
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