Shobini Jayaraman

Molecular basis for non-invasive diagnostics of cardiac amyloids using bone tracers Amyloid diseases including Alzheimer’s, Parkinson’s and over 30 others and are incurable life-threatening disorders caused by abnormal protein deposition as fibrils in various organs. Cardiac amyloidosis is particularly challenging to diagnose and treat.

Highlights Calcified areas in aortic valves often co-localize with amyloid fibrils that can promote calcification. Patient-derived amyloid fibrils contain arrays of acidic residues that can bind calcium and organize calcium phosphate nucleation clusters, while collagen fibrils guide crystal growth. This process is akin to functional biomineralization guided by Ca entrapment by acidic arrays in proteins, including amyloids.

S. Jayaraman, D. L. Gantz, C. Haupt, M. Faendrich and O. Gursky, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC01424H If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using RightsLink. Go to our Instructions for using RightsLink page for details.