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Abstract Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is crucial for mitochondrial function and biogenesis. However, whether and how PGC-1α can regulate hepatocyte ferroptosis during the pathogenic process of metabolic dysfunction-associated steatohepatitis (MASH) has not been clarified. Hepatocyte ferroptosis was assessed in the liver of MASH patients and in vivo and in vitro MASH models.
1Graduate School of Hebei North University, Zhangjiakou, Hebei Province, China 2Department of Gastroenterology, Air Force Medical Center, Chinese People's Liberation Army, Beijing, China Background and objective: Transjugular intrahepatic portosystemic shunt (TIPS) is an important intervention for relieving portal hypertension-related complications in patients with decompensated cirrhosis.
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