Xiuying Zhang
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Marked and reversible circulating insulin-like growth factor-1 elevation during teprotumumab N01 treatment for thyroid eye disease with limited correspondence to glycemic changes
Abstract Background: Insulin-like growth factor-1 (IGF-1) receptor (IGF-1R) inhibitors have changed the treatment landscape for moderate-to-severe thyroid eye disease (TED), but the longitudinal behavior of circulating IGF-1 during and after therapy remains insufficiently characterized. This study aimed to describe serum IGF-1 dynamics in patients with TED treated with IGF-1R inhibitor teprotumumab N01 and to explore their relationship with glycemic changes.
PGC-1α protects against MASH via Tim23-dependent inhibition of DRP1-mediated ferroptosis - Cell Death & Disease
Abstract Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is crucial for mitochondrial function and biogenesis. However, whether and how PGC-1α can regulate hepatocyte ferroptosis during the pathogenic process of metabolic dysfunction-associated steatohepatitis (MASH) has not been clarified. Hepatocyte ferroptosis was assessed in the liver of MASH patients and in vivo and in vitro MASH models.
Redefining evidence for teprotumumab in thyroid eye disease: an updated meta-analysis of efficacy and safety
Introduction Thyroid eye disease (TED), also known as Graves’ orbitopathy, is an autoimmune inflammatory disorder of the orbit that is both disfiguring and potentially sight-threatening. It represents the most common orbital disease in adults, with an estimated annual incidence of 16 per 100,000 women and 3 per 100,000 men (1).
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