Xiuying Zhang
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Marked and reversible circulating insulin-like growth factor-1 elevation during teprotumumab N01 treatment for thyroid eye disease with limited correspondence to glycemic changes
Abstract Background: Insulin-like growth factor-1 (IGF-1) receptor (IGF-1R) inhibitors have changed the treatment landscape for moderate-to-severe thyroid eye disease (TED), but the longitudinal behavior of circulating IGF-1 during and after therapy remains insufficiently characterized. This study aimed to describe serum IGF-1 dynamics in patients with TED treated with IGF-1R inhibitor teprotumumab N01 and to explore their relationship with glycemic changes.
Mechanistic Insights into Maxing Shigan Decoction in Community-Acquired Pneumonia Based on Bioinformatics and Experimental Validation
Back to Journals » Infection and Drug Resistance » Volume 19 Authors Wei C , Wang R, Zhang X , Yang M, Zhang S, Zhao H, Zhang L Received 3 July 2026 Accepted for publication 27 August 2026 Published 5 September 2026 Volume 2026:19 637858 DOI https://doi.org/10.2147/IDR.S637858 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Hazrat Bilal Chenhao Wei,1,* Rui Wang,1,* Xiuying Zhang,2 Mengfei Yang,1 Shiyao...
PGC-1α protects against MASH via Tim23-dependent inhibition of DRP1-mediated ferroptosis - Cell Death & Disease
Abstract Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is crucial for mitochondrial function and biogenesis. However, whether and how PGC-1α can regulate hepatocyte ferroptosis during the pathogenic process of metabolic dysfunction-associated steatohepatitis (MASH) has not been clarified. Hepatocyte ferroptosis was assessed in the liver of MASH patients and in vivo and in vitro MASH models.
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