Shouqin Lü

Get full text access Log in, subscribe or purchase for full access. References 1. Granger, D.N. ∙ Kubes, P. The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion J. Leukoc. Biol. 1994; 55:662-675 2. Springer, T.A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm Cell. 1994; 76:301-314 3. McEver, R.P. Adhesive interactions of leukocytes, platelets, and the vessel wall during hemostasis and inflammation Thromb. Haemostasis.

Abstract Synthetic signaling receptors enable programmable cellular responses coupling with customized inputs. However, engineering a designer force-sensing receptor to rewire mechanotransduction remains largely unexplored. Herein, we introduce nongenetically engineered artificial mechanoreceptors (AMRs) capable of reprogramming non-mechanoresponsive receptor tyrosine kinases (RTKs) to sense user-defined force cues, enabling de novo-designed mechanotransduction.

Abstract Hepatic sinusoids present complex anatomical structures such as the endothelial sieve pores and the Disse space, which govern the microscopic blood flow in the sinusoids and are associated with structural variations in liver fibrosis and cirrhosis. However, the contributions of the permeability of endothelial and collagen layers and the roughness of hepatocyte microvilli to the features of this microflow remain largely unknown.