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Articles

Slow RNAPII elongation enhances naive pluripotency rewiring while maintaining high replication fork speed

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By En-Ze Li, Jing Wang, Jiaxi Li, Sara Martin-Virgala, Joana Segura, Alicia Gallego, Ran Tong, Jesús Rafael Rodríguez-Aguilera, Biswajit Das, Javier Isoler-Alcaraz, Carlos Gallego-García, shraddha shinde, Andrei Chabes, Lothar Schermelleh, Maria Leticia Gomez, María Gómez, Sara Tur-Gracia, Magdalena M. Maslon
| Science Magazine Verified
Abstract DNA replication and transcription must be intricately coordinated as both machineries navigate the same chromatin landscape to ensure genome stability and proper cell function. Here, we show that altering their elongation rates—specifically, slowed transcriptional elongation alongside rapid replication fork progression—does not elicit replicative stress.
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Work loss among privately insured employees with overweight and obesity in the United States

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By shraddha shinde, Anh Tran, Michelle Jerry
| Wiley Online Library Verified
1 BACKGROUND Obesity is a significant public health issue with a steadily rising prevalence from 31% of the United States (US) adult population in 1999-2000 to 42% of the US adult population in 2017–2020.1 Obesity is associated with numerous conditions, including heart disease, stroke, and type 2 diabetes, which are among the leading causes of preventable morbidity and mortality.2 A systematic review of 50 studies published between January 2000 and June 2017 concluded that there are...
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