Shuaipeng Ma

Keywords reactive gliosis astrocytes microglia GADD45G MAP3K4 synapse loss Alzheimer’s disease glia-neuron interactions NF-κB IRF3 Get full text access Log in, subscribe or purchase for full access. References 1. Verkhratsky, A. ∙ Nedergaard, M. Physiology of Astroglia Physiol. Rev. 2018; 98:239-389 2. Allen, N.J. Astrocyte regulation of synaptic behavior Annu. Rev. Cell Dev. Biol. 2014; 30:439-463 3.

Abstract Effective therapeutics is much needed for amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease mainly affecting motor neurons. By screening chemical compounds in human patient-derived and aging-relevant motor neurons, we identify a neuroprotective compound and show that MAP4Ks may serve as therapeutic targets for treating ALS. The lead compound broadly improves survival and function of motor neurons directly converted from human ALS patients.

This is a preprint. It has not yet been peer reviewed by a journal. The National Library of Medicine is running a pilot to include preprints that result from research funded by NIH in PMC and PubMed. bioRxiv. Display options Format doi: 10.1101/2023.04.24.538014.