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Shuaipeng Ma

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Articles

GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration

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By Tianjin Shen, Wenjiao Tai, Dongfang Jiang, Shuaipeng Ma, Xiaoling Zhong, Yuhua Zou, Chun-Li Zhang
| Cell Press Verified
Keywords reactive gliosis astrocytes microglia GADD45G MAP3K4 synapse loss Alzheimer’s disease glia-neuron interactions NF-κB IRF3 Get full text access Log in, subscribe or purchase for full access. References 1. Verkhratsky, A. ∙ Nedergaard, M. Physiology of Astroglia Physiol. Rev. 2018; 98:239-389 2. Allen, N.J. Astrocyte regulation of synaptic behavior Annu. Rev. Cell Dev. Biol. 2014; 30:439-463 3.
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Screens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease - Cell Death & Disease

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By Shuaipeng Ma
| Nature Verified
Abstract Effective therapeutics is much needed for amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease mainly affecting motor neurons. By screening chemical compounds in human patient-derived and aging-relevant motor neurons, we identify a neuroprotective compound and show that MAP4Ks may serve as therapeutic targets for treating ALS. The lead compound broadly improves survival and function of motor neurons directly converted from human ALS patients.
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Chemical screens in aging-relevant human motor neurons identify MAP4Ks as therapeutic targets for amyotrophic lateral sclerosis

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By Shuaipeng Ma, Wenjiao Tai, Xiaoling Zhong, Meng-Lu Liu
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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