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Shuangying Jiang

As seen in: Nature, Genome Biology, BioRxiv
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Articles

Large-scale genomic rearrangements boost SCRaMbLE in Saccharomyces cerevisiae - Nature Communications

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By Wenfei Yu, Shuangying Jiang, Marco Monti, Weimin Zhang, Chunhui Hou, Yizhi Cai, Jef Boeke
| Nature Verified
Abstract Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution (SCRaMbLE) is a promising tool to study genomic rearrangements. However, the potential of SCRaMbLE to study genomic rearrangements is currently hindered, because a strain containing all 16 synthetic chromosomes is not yet available. Here, we construct SparLox83R, a yeast strain containing 83 loxPsym sites distributed across all 16 chromosomes.
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Building a eukaryotic chromosome arm by de novo design and synthesis - Nature Communications

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By Shuangying Jiang, Jie Wu, Zelin Cai, Wenfei Yu, Marco Monti, Daniel E. Schindler, Weimin Zhang, Yizhi Cai, Jef Boeke, Qiao Zhao
| Nature Verified
Abstract The genome of an organism is inherited from its ancestor and continues to evolve over time, however, the extent to which the current version could be altered remains unknown. To probe the genome plasticity of Saccharomyces cerevisiae, here we replace the native left arm of chromosome XII (chrXIIL) with a linear artificial chromosome harboring small sets of reconstructed genes.
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High plasticity of ribosomal DNA organization in budding yeast

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By Shuangying Jiang, Yun Wang, Cheng Zeng, Zelin Cai
| BioRxiv
Abstract In eukaryotic genomes, ribosomal DNA (rDNA) generally resides as a highly repetitive and dynamic structure, making it difficult to study. Here, a synthetic rDNA array on chromosome III in budding yeast was constructed to serve as the sole source of rRNA. Utilizing the loxPsym site within each rDNA repeat and the Cre recombinase, we were able to reduce the copy number to as few as eight copies.
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