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Shuangying Jiang on Muck Rack

Shuangying Jiang

As seen in: Nature, Genome Biology, BioRxiv
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Articles

High-throughput synthesis of DNA fragments by molecular self-assembly of overlapping oligonucleotides

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By Zhiguang Wu, Zhengyang Sun, Shuangying Jiang, Yaqi Wang, Cheng Zeng, Zelin Cai, Chenghao Su, Xiandi Zhang, Yunan Chen, Yue Shen, Chenyou Zhu, Ye Xiang, Fang Fang, Ninuo Xia, Dongsheng Liu, Junbiao Dai, Bryan Wei, Tanxi Bai
| Nature Verified
Abstract The limitations of DNA synthesis technologies are a fundamental bottleneck in synthetic biology. Here we present a high-throughput gene synthesis method driven by hybridization, called Molecular Self-Assembly Induced Cloning. Molecular Self-Assembly Induced Cloning overcomes molecular crosstalk and oligo misalignment across genes by coupling orthogonal self-assembly of overlapping DNA segments in vitro with the DNA repair machineries of host cells in vivo.
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Large-scale genomic rearrangements boost SCRaMbLE in Saccharomyces cerevisiae - Nature Communications

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By Wenfei Yu, Shuangying Jiang, Marco Monti, Weimin Zhang, Chunhui Hou, Yizhi Cai, Jef Boeke
| Nature Verified
Abstract Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution (SCRaMbLE) is a promising tool to study genomic rearrangements. However, the potential of SCRaMbLE to study genomic rearrangements is currently hindered, because a strain containing all 16 synthetic chromosomes is not yet available. Here, we construct SparLox83R, a yeast strain containing 83 loxPsym sites distributed across all 16 chromosomes.
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Building a eukaryotic chromosome arm by de novo design and synthesis - Nature Communications

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By Shuangying Jiang, Jie Wu, Zelin Cai, Wenfei Yu, Marco Monti, Daniel E. Schindler, Weimin Zhang, Yizhi Cai, Jef Boeke, Qiao Zhao
| Nature Verified
Abstract The genome of an organism is inherited from its ancestor and continues to evolve over time, however, the extent to which the current version could be altered remains unknown. To probe the genome plasticity of Saccharomyces cerevisiae, here we replace the native left arm of chromosome XII (chrXIIL) with a linear artificial chromosome harboring small sets of reconstructed genes.
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