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Shuchan Li

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53BP1 orchestrates sequence feature of RAG targets to balance DNA repair outcomes during V(D)J recombination

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By Robert A Kozol, Peishi Rao, Yvonne T. Kschonsak, Sha Luo, Hailiang Zha, Zifan Yang, Shuchan Li, Leyi Yu, Ruolin Qiao, Ruoxi Kong, Yifan Wang Verified, Junhong Guan, Xuefei Zhang
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract RAG endonuclease initiates V(D)J recombination by cleaving recombination signal sequences (RSSs), subsequently repaired by classical nonhomologous end-joining (c-NHEJ). However, 53BP1, as a key DNA damage response (DDR) factor promoting c-NHEJ, is dispensable for V(D)J recombination.
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