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Articles by Shuming Wang
Atlas of genetic architecture and exploratory temporal interaction networks of plasma protein-based organ and system aging
Abstract Organ-level investigations provide insights into inter-individual heterogeneity in health and disease, yet aging across organs and systems remains incompletely understood.
The crosstalk between RNA m6A modification and protein lactylation: emerging insights into tumor progression
Abstract N6-methyladenosine (m6A) is one of the most important RNA modifications and is widely distributed across mRNAs and non-coding RNAs. Its deposition, removal, and recognition are dynamically regulated by a set of proteins, including methyltransferases (writers), demethylases (erasers), and binding proteins (readers).
Full-color 3D visualization with Janus metafiber
Abstract Fiber endoscopic imaging system exhibits high-precision imaging capability in extreme scenarios due to its flexibility and compatibility. The fiber bundles are naturally suitable to collect 2D intensity information, but it is difficult to directly obtain depth or angle information. Therefore, a large number of complex optical components are usually required to achieve dual-function imaging.
Scalable generalized meta-spanners enabling parallel multitasking optical manipulation
Abstract Optical manipulation techniques offer exceptional contactless control but are fundamentally limited in their ability to perform parallel multitasking. To achieve high-density, versatile manipulation with subwavelength photonic devices, it is essential to sculpt light in multiple dimensions.
Forelimb Motor Learning and Memory Consolidation Drives Distinct Oligodendrocyte Plasticity to Regulate Task‐related Neuronal Activity
1 Introduction In the central nervous system (CNS), oligodendrocytes (OLs) extend numerous myelin sheaths to enwrap axons, thereby accelerating action potential conduction, providing metabolic support, and maintaining axonal integrity.[1-3] Myelination develops in a similar way in humans and mice, with basic myelination completed in the early postnatal period (first 6 weeks in mice and adolescence in humans), followed by subtle changes with life experience, and demyelination in the ageing...
Hypomyelination in autism-associated neuroligin-3 mutant mice impairs parvalbumin interneuron excitability, gamma oscillations, and sensory discrimination | Nature Communications
Abstract Whether and how myelin plasticity, an emerging new form of brain plasticity, is involved in autism spectrum disorder (ASD) remains unknown. Here, we identify deficits in oligodendrocyte (OL) generation and myelination in the barrel cortex (BC) of the male NL3-R451C-KI mouse model of ASD. These mice also show impaired texture recognition, disrupted gamma neuronal oscillations, and reduced excitability and myelination level in the BC-PV interneuron.
Exploring the relationship between governance mechanisms and contractor behaviors: insights from fairness perception
In recent years, China’s urbanization process has been accelerating, resulting in strong demand for infrastructure construction (Wu et al. Citation2023; Zeng et al. Citation2019). Against this backdrop, the government has increased its investment in key sectors such as transportation, energy, water resources, and environmental protection, aiming to promote economic development and social progress (Du, Zhang, and Han Citation2022; Sun and Zhou Citation2019; Zhou, Raza, and Sui Citation2021).
An Efficient System for Mesophyll Protoplast Isolation, Purification, and Transformation in Loquat: Studies on Fluorescent Marker Analysis and Subcellular Localization
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Progress in AAV-Mediated In Vivo Gene Therapy and Its Applications in Central Nervous System Diseases
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Facility Location Under Uncertainty
2024 | Buch This textbook provides researchers, post-graduate students, and practitioners with a systematic framework for coping with uncertainty when making facility location decisions. In addition to in-depth coverage of models and solution techniques, application areas are discussed. The book guides readers through the field, showing how to successfully analyze new problems and handle new applications. Initially, the focus is on base models and concepts.
LUKB: Preparing Local UK Biobank Data for Analysis
The authors have declared no competing interest. This study was funded by the Shanghai Rising-Star Program (21QB1400900), and the National Natural Science Foundation of China (32100510) and has been conducted using the UK Biobank Resource under Application Number 103791. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Propagating dimensions of light: Deforming versatile non-diffractive beams along the optical trajectory
The diffraction of light is a ubiquitous phenomenon in nature where waves spread out as they propagate. This spreading of light beams during propagation limits the efficient transmission of energy and information. Therefore, scientists have endeavored to suppress diffraction effects to better maintain the shape and direction of light beams. Over the past few decades, there have been significant breakthroughs in controlling the structure of light.
Research on seismic response and dynamic lateral pressure of the silo model under dynamic interaction between granular materials and the silo wall
CONFLICT OF INTEREST STATEMENT The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. REFERENCES 1, . The experimental study of earthquake response of R.C. cylinder silos. Special Struct. 1994; 11(4): 55–58, 2. 2, . Study on calculating theory of seismic response of silos. China Civ Eng J. 1997; 30(1): 25–30. 3, , , , , .
Reversible lateral optical force on phase-gradient metasurfaces for full control of metavehicles
Abstract Photonics is currently undergoing an era of miniaturization thanks in part to two-dimensional (2D) optical metasurfaces. Their ability to sculpt and redirect optical momentum can give rise to an optical force, which acts orthogonally to the direction of light propagation. Powered by a single unfocused light beam, these lateral optical forces (LOFs) can be used to drive advanced metavehicles and are controlled via the incident beam’s polarization.
Ultra-compact snapshot spectral light-field imaging - Nature Communications
Abstract Ideal imaging, which is constantly pursued, requires the collection of all kinds of optical information of the objects in view, such as three-dimensional spatial information (3D) including the planar distribution and depth, and the colors, i.e., spectral information (1D).
Achromatic metalens array for full-colour light-field imaging
Abstract A light-field camera captures both the intensity and the direction of incoming light1,2,3,4,5. This enables a user to refocus pictures and afterwards reconstruct information on the depth of field. Research on light-field imaging can be divided into two components: acquisition and rendering. Microlens arrays have been used for acquisition, but obtaining broadband achromatic images with no spherical aberration remains challenging.
A broadband achromatic metalens in the visible
Metalenses consist of an array of optical nanoantennas on a surface capable of manipulating the properties of an incoming light wavefront. Various flat optical components, such as polarizers, optical imaging encoders, tunable phase modulators and a retroreflector, have been demonstrated using a metalens design.
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