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Shuming Yin on Muck Rack

Shuming Yin

As seen in: Nature
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Articles

Author Correction: Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain

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By Xiaohui Zhang, Liang Chen, Biyun Zhu, Liren Wang, Caiyu Chen, Mengjia Hong, Yifan Huang, Huiying Li, Shuming Yin, Zuozhen Yang, Meizhen Liu, Ying Zhang, Zhiyong Mao, Yuxuan Wu, Mingyao Liu, Honghui Han, Bailian Cai, Weishi Yu
| Nature Verified
Correction to: Nature Cell Biologyhttps://doi.org/10.1038/s41556-020-0518-8, published online 11 May 2020. Since the version of the article initially published, errors have been found requiring five corrections. Please note that the corrections do not affect the key findings and conclusions of our article.
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Engineered Un1Cas12f1 for multiplex genome editing with enhanced activity and targeting scope - Nature Communications

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By Yanan Huo, Jiale Mei, Dan Zhang, Dexin Zhang, Chao Dong, Shuming Yin, Meizhen Liu, Xinyan Wang, Dan Chen, Yuting Guan, Gaojie Song, Bing Du, Yongming Wang, Zongli Zheng, Hong liu, Liren Wang
| Nature Verified
Abstract The compact CRISPR-Cas12f system is promising for AAV-delivered gene therapy, but its application has been constrained by restrictive PAM recognition (e.g., TTTR) and suboptimal editing efficiency. Through bacterial library screening and mammalian cell validation, we engineer evoCas12f, an optimized variant incorporating five key mutations, that dramatically expands PAM recognition to NTNR/NYTR.
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