Shuying Sun

Keywords microglia KAT7 mitochondrial DNA CMPK2 cGAS-STING neuroinflammation Alzheimer’s disease Introduction Alzheimer’s disease (AD) is the most common cause of dementia, affecting tens of millions worldwide and imposing an ever-growing societal and economic burden.1 It is neuropathologically characterized by the accumulation of extracellular β-amyloid (Aβ) plaques and intracellular neurofibrillary tangles of hyperphosphorylated tau.2 Yet, decades of research targeting these hallmark...

ArticleOnline nowOpen access Affiliations & Notes 1Department of Physiology, Pharmacology & Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 2Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 3Cellular and Molecular Physiology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 4Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL...

Keywords ALS FTD C9ORF72 CRISPR screening poly-GR/PR PTPσ PI3P endosome lysosome Get full text access Log in, subscribe or purchase for full access. References 1. Boillée, S. ∙ Vande Velde, C. ∙ Cleveland, D.W. ALS: a disease of motor neurons and their nonneuronal neighbors Neuron. 2006; 52:39-59 2. Bang, J. ∙ Spina, S. ∙ Miller, B.L. Frontotemporal dementia Lancet. 2015; 386:1672-1682 3. Ling, S.C. ∙ Polymenidou, M.