Si-Jun Hu on Muck Rack

Si-Jun Hu

As seen in: Cell Reports
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By Jun-Long Zhao, Yu-Chen Ye, Chun-Chen Gao, Liang Wang, Ru Jiang, Jian Bai, Yong-Zhan Nie, Yan Chen, Xiao-Fei Li, Wei Zhang, Hua Han, Hong-yan Qin, Kai-Xi Ren, Si-Jun Hu, Shi-Qian Liang, Jia-Long Liang, Peng-Fei Ma, Yi-Yang Hu, Ben-Chang Li
| Cell Reports Verified
Highlights • Notch signaling represses MCT2-mediated lactate transport in myeloid cells • Lactate promotes M-MDSC differentiation into G-MDSCs rather than mature macrophages • Lactate interacts with intracellular c-Jun to protect from FBW7-mediated degradation • Combining Notch activation and MCT2 inhibition in myeloid cells represses tumor growth Summary Myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) play critical roles in tumorigenesis.
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