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Si-ying Sun on Muck Rack

Si-ying Sun

As seen in: Nature
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STK40 inhibits profibrotic Arg1 + macrophage differentiation and renal fibrosis by regulating poly-ubiquitination of STAT3

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By Jun Ni, Jia Li, Jia-min Liu, Xin Li Verified, Xi-Yu Liu, Zhe Ji, Hui-Yao Lan, Dan-Dan Zhang, Si-ying Sun, Zhen-yan Jiang, Yue-xiao Tao, Hui-zi Wang, Ge-ge He, Xue-zhu Li, Xue-feng Wu
| Nature Verified
Abstract Monocyte-derived macrophages are central drivers of chronic renal inflammation and fibrosis, yet the regulatory mechanisms that restrain their profibrotic differentiation remain poorly defined. Here, we identified serine/threonine kinase 40 (STK40) as a suppressor of profibrotic macrophage differentiation and renal fibrosis progression. Myeloid-specific Stk40 deletion exacerbated renal fibrosis in multiple mouse models.
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