Sierra M Barone

Abstract RNA-based vaccines against SARS-CoV-2 have proven critical to limiting COVID-19 disease severity and spread. Cellular mechanisms driving antigen-specific responses to these vaccines, however, remain uncertain. Here we identify and characterize antigen-specific cells and antibody responses to the RNA vaccine BNT162b2 using multiple single-cell technologies for in depth analysis of longitudinal samples from a cohort of healthy participants.

Discussion Asthma is an inflammatory disease driven in part by different T cell subsets that vary with the clinical subtype (3, 37). T cell subsets and functional populations are now known to have diverse metabolic requirements to activate, proliferate, and function (7–12). To date, however, these changes have not been well established or tested in airway inflammation.

Diana C. Contreras Healey, Jacqueline Y. Cephus, Sierra M. Barone, Nowrin U. Chowdhury, Debolanle O. Dahunsi, Matthew Z. Madden, Xiang Ye, Xuemei Yu, Kellen Olszewski, Kirsten Young, Valerie A. Gerriets, Peter J. Siska, Ryszard Dworski, Jonathan Hemler, Jason W. Locasale, Masha V. Poyurovsky, R. Stokes Peebles Jr., Jonathan M. Irish, Dawn C. Newcomb and Jeffrey C.